ArticleEcotoxicology and environmental safety2021
Differential impacts of particulate air pollution exposure on early and late stages of spermatogenesis.
Article in Ecotoxicology and environmental safety, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Association of sulfur dioxide exposure with sperm quality in reproductive-aged men: the mediating and moderating roles of essential elements in seminal plasma.Asian journal of andrology · 2026Article
- Critical Windows of Air Pollution Exposure During Spermatogenesis and Intrauterine Insemination Outcomes.Paediatric and perinatal epidemiology · 2026Article
- Baicalin Protects Mouse Testis From Injury Induced by PMJournal of biochemical and molecular toxicology · 2026Article
- The silent threat: PMArchives of toxicology · 2026Review
- Environmental and microbiome determinants of sperm quality: a narrative review on male health.Translational andrology and urology · 2026Review
- Exploring the nexus between particulate matter and infertility: Multiple mechanistic insights and potential control strategies.iScience · 2026Review
- Individual and Joint Effect of Particulate Matter and Night-Time Temperature on Sperm Quality: A Large Retrospective Cohort Study in China.Environment & health (Washington, D.C.) · 2026Article
- Ambient air pollution during developmental windows of spermatogenesis and semen quality among an infertility treatment seeking population.Ecotoxicology and environmental safety · 2025Article
- Ambient air pollution in critical windows of exposure and spontaneous miscarriage in a preconception cohort.Environmental research · 2025Article
- Identifying critical windows of air pollution exposure and semen quality: A cross-sectional study in Chinese fertile men.BMC public health · 2025Article
- Beyond Genes: Mechanistic and Epidemiological Insights into Paternal Environmental Influence on Offspring Health.Current environmental health reports · 2025Review
- Associations Between Ambient PMToxics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDespite increasing evidence that particulate air pollution has adverse effects on human semen quality, few studies examine the impact of air pollution on clinically relevant thresholds used to diagnose male fertility problems. Furthermore, exposure is often assessed using average air pollution levels in a geographic area rather than individualized estimates. Finally, physiologically-informed exposure windows are inconsistent.
objectivesWe sought to test the hypothesis that airborne particulate exposures during early-phase spermatogenesis will have a differential impact on spermatogenic formation compared to late-phase exposures, using an individualized model of exposure to particulate matter ≤ 2.5 µm and ≤ 10 µm (PM
methodsFrom an original cohort of 183 couples, we conducted a retrospective analysis of 130 healthy males seeking to become parents, using spermatogenesis-relevant exposure windows of 77-34 days and 37-0 days prior to semen collection to encompass sperm development stages of mitosis/meiosis and spermiogenesis, respectively. Individualized residential exposure to PM
resultsDuring the early phase of spermatogenesis, air pollution exposure is associated with 1.52 (95% CI: 1.04-2.32) times greater odds of < 30% normal heads per 1-unit increase in IQR for PM
conclusionParticulate exposure has a differential and more deleterious impact on sperm during early-phase spermatogenesis than late-phase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.