Evidence map›Paper›PMID 34126261›Full record

ArticleRespiratory physiology & neurobiology2021

Interaction between the pulmonary stretch receptor and pontine control of expiratory duration.

Edward J Zuperku, Francis A Hopp, Eckehard A E Stuth, Astrid G Stucke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Edward J ZuperkuClement J. Zablocki Department of Veterans Affairs Medical Center, Milwaukee, WI, 53295 USA; Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address: ezuperku@mcw.edu.
Francis A HoppClement J. Zablocki Department of Veterans Affairs Medical Center, Milwaukee, WI, 53295 USA. Electronic address: fhopp@mcw.edu.
Eckehard A E StuthDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Pediatric Anesthesia, Children's Hospital of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address: estuth@mcw.edu.
Astrid G StuckeDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Pediatric Anesthesia, Children's Hospital of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address: astucke@mcw.edu.
Children's Hospital of Wisconsin · USMedical College of Wisconsin · USMilwaukee VA Medical Center · US

Funding

Mechanisms of opioid and sedative-induced respiratory depressionR01HL159546 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI STUCKE, ASTRID G · 2021 to 2024
$1.9M
Age-dependent differences in opioid-induced respiratory depressionR01GM112960 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI STUCKE, ASTRID G · 2015 to 2019
$1.2M
Neuropharmacology of Pontine Control of Breathing FrequencyI01BX000721 · VA · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · PI ZUPERKU, EDWARD J · 2011 to 2018
–
BLRD VA I01 BX000721NHLBI NIH HHS R01 HL159546NIGMS NIH HHS R01 GM112960
6 · The paper itself

Abstract

Medial parabrachial nucleus (mPBN) neuronal activity plays a key role in controlling expiratory (E)-duration (TE). Pulmonary stretch receptor (PSR) activity during the E-phase prolongs TE. The aims of this study were to characterize the interaction between the PSR and mPBN control of TE and underlying mechanisms. Decerebrated mechanically ventilated dogs were studied. The mPBN subregion was activated by electrical stimulation via bipolar microelectrode. PSR afferents were activated by low-level currents applied to the transected central vagus nerve. Both stimulus-frequency patterns during the E-phase were synchronized to the phrenic neurogram; TE was measured. A functional mathematical model for the control of TE and extracellular recordings from neurons in the preBötzinger/Bötzinger complex (preBC/BC) were used to understand mechanisms. Findings show that the mPBN gain-modulates, via attenuation, the PSR-mediated reflex. The model suggested functional sites for attenuation and neuronal data suggested correlates. The PSR- and PB-inputs appear to interact on E-decrementing neurons, which synaptically inhibit pre-I neurons, delaying the onset of the next I-phase.

Indexed as

AnimalsDogsElectric StimulationExhalationParabrachial NucleusPulmonary Stretch ReceptorsReflexTime FactorsE-decrementing neuronsGain modulationHering-Breuer reflexPontine medial parabrachial nucleusPre-I neuronsPulmonary stretch receptors

Identifiers

PMID34126261
PMCPMC8418273
OpenAlexW3169286713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.