ArticleNeuroImage2021
Fear extinction learning modulates large-scale brain connectivity.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial.Neurobiology of learning and memory · 2023Trial
- The physiological foundation of extinction improvement by tDCS over the ventromedial prefrontal cortex (vmPFC) in healthy humans: an fMRI study.Translational psychiatry · 2026Article
- A brain-state-informed framework for simultaneous extinction of fear and functional magnetic resonance imaging acquisition in rodents.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- How Fear Memory is Updated: From Reconsolidation to Extinction?Neuroscience bulletin · 2025Review
- Infralimbic Projections to the Substantia Innominata-Ventral Pallidum Constrain Defensive Behavior during Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Current State of the Neuroscience of Fear Extinction and Its Relevance to Anxiety Disorders.Current topics in behavioral neurosciences · 2025Review
- State-dependent memory mechanisms insights from neural circuits and clinical implications.Frontiers in cellular neuroscience · 2025Review
- Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Data-driven, connectome-wide analysis identifies psychosis-specific brain correlates of fear and anxiety.Molecular psychiatry · 2024Article
- Reducing FKBP51 Expression in the Ventral Hippocampus Decreases Auditory Fear Conditioning in Male Rats.International journal of molecular sciences · 2024Article
- Distributed neural representations of conditioned threat in the human brain.Nature communications · 2024Article
- Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Broadening the scope: Multiple functional connectivity networks underlying threat conditioning and extinction.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The influence of sleep on fear extinction in trauma-related disorders.Neurobiology of stress · 2023Article
- Neuroimaging of Fear Extinction.Current topics in behavioral neurosciences · 2023Review
- Beyond Fear, Extinction, and Freezing: Strategies for Improving the Translational Value of Animal Conditioning Research.Current topics in behavioral neurosciences · 2023Article
- Fear Extinction Learning in Posttraumatic Stress Disorder.Current topics in behavioral neurosciences · 2023Article
- Is Fear Extinction Impairment Central to Psychopathology?Current topics in behavioral neurosciences · 2023Article
- Human fear neurobiology reimagined: Can brain-derived biotypes predict fear-based disorders after trauma?Neuroscience and biobehavioral reviews · 2023Review
- Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods.Neuroscience and biobehavioral reviews · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Exploring the neural circuits of the extinction of conditioned fear is critical to advance our understanding of fear- and anxiety-related disorders. The field has focused on examining the role of various regions of the medial prefrontal cortex, insular cortex, hippocampus, and amygdala in conditioned fear and its extinction. The contribution of this 'fear network' to the conscious awareness of fear has recently been questioned. And as such, there is a need to examine higher/multiple cortical systems that might contribute to the conscious feeling of fear and anxiety. Herein, we studied functional connectivity patterns across the entire brain to examine the contribution of multiple networks to the acquisition of fear extinction learning and its retrieval. We conducted trial-by-trial analyses on data from 137 healthy participants who underwent a two-day fear conditioning and extinction paradigm in a functional magnetic resonance imaging (fMRI) scanner. We found that functional connectivity across a broad range of brain regions, many of which are part of the default mode, frontoparietal, and ventral attention networks, increased from early to late extinction learning only to a conditioned cue. The increased connectivity during extinction learning predicted the magnitude of extinction memory tested 24 h later. Together, these findings provide evidence supporting recent studies implicating distributed brain regions in learning, consolidation and expression of fear extinction memory in the human brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.