ArticleCancer letters2021
Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids.
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In one paragraph
Article in Cancer letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
107 citing papers in PubMed, 144 citations in OpenAlex.
- Pregnancy promotes tumor metastasis through adenosine-induced immunosuppressive neutrophils in pre-metastatic microenvironment.Nature communications · 2026Article
- Cancer stem cell plasticity: mechanisms, immune microenvironment crosstalk, and therapeutic implications.Journal of hematology & oncology · 2026Review
- Gastric Cancer Organoids: Mechanistic Insights, Drug Discovery, and Translational Advances in Precision Medicine.Journal of gastric cancer · 2026Review
- New developments and applications of human organoids.Nature reviews. Molecular cell biology · 2026Review
- WTAP-mediated mMolecular genetics and genomics : MGG · 2026Article
- DP103 as a critical modulator of Wnt signaling and cancer stemness: implications for precision treatment in triple negative breast cancer.Cell death & disease · 2026Article
- Midkine as a novel prognostic and therapeutic target in meningioma: insights from single-cell analysis and organoid-based drug validation.Journal of translational medicine · 2026Article
- Tumor Organoid and Microenvironment Cocultures: Implications for Basic and Translational Cancer Research.MedComm · 2026Review
- Review
- Spatially defined danger zone shapes gastric cancer progression through CCDC80Apoptosis : an international journal on programmed cell death · 2026Article
- Walking the tightrope: Balancing immune checkpoints and their inhibitors in host defence against bacterial infections.Journal of applied biomedicine · 2026Review
- Involvement of increased arginase-1The Journal of international medical research · 2026Article
- Methods and applications of patient-derived organoid models for immune microenvironment and immunotherapy research in multiple cancer types.Experimental hematology & oncology · 2026Review
- From bench to knowledge graph: mapping the global evolution of PD-1/PD-L1 immunotherapy in gastric cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- The dual role of the Notch signaling pathway in digestive system cancers.European journal of medical research · 2026Review
- Immunotherapy rechallenge in gastric cancer: resistance mechanisms, molecular stratification, and precision decision-making.Frontiers in immunology · 2026Review
- Tumor organoid-immune cell co-culture systems for precision oncology.Frontiers in cell and developmental biology · 2026Review
- Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From benchside avatars to bedside breakthroughs: Patient-derived organoids in the new era of cancer immunotherapy.Translational oncology · 2026Review
- Myeloid-derived suppressor cells modulation in the context of tumor microenvironment for gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 2 countries.
Vivien KohNational University Cancer Institute Singapore, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Jayati ChakrabartiDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
Meaghan TorvundDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
Nina SteeleDepartment of Cell and Developmental Biology and Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
Jennifer A HawkinsDepartment of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Yoshiaki ItoCancer Science Institute of Singapore, National University of Singapore, Singapore.
Jiang WangDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Michael A HelmrathDepartment of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Juanita L MerchantDepartment of Gastroenterology and Hepatology, University of Arizona College of Medicine, Tucson, AZ, USA.
Syed A AhmedDepartment of Surgery, University of Cincinnati Cancer Institute, Cincinnati, OH, USA.
Asim ShabbirDepartment of Surgery, National University Hospital, Singapore.
Jimmy Bok Yan SoNational University Cancer Institute Singapore, National University Health System, Singapore; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Wei Peng YongNational University Cancer Institute Singapore, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Yana ZavrosDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: yzavros@email.arizona.edu.
National University of Singapore · SGUniversity of Arizona · USCincinnati Children's Hospital Medical Center · USNational University Hospital · SGUniversity of Cincinnati · USUniversity of Cincinnati Medical Center · USUniversity of Michigan · US
Funding
VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2MStem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4MOrganoids as a Model System for Studying Gastrointestinal DiseaseU19AI116491 · NIAID · UNIVERSITY OF CINCINNATI · PI WEISS, ALISON A. · 2015 to 2019
$4.6MThe role of Hedgehog Signaling in gastric tissue repair and regenerationR01DK083402 · NIDDK · UNIVERSITY OF CINCINNATI · PI ZAVROS, YANA · 2011 to 2019
$3.7MMDSC Polarization and Helicobacter-Induced Gastric MetaplasiaR01DK118563 · NIDDK · UNIVERSITY OF ARIZONA · PI MERCHANT, JUANITA L. · 2018 to 2021
$1.4MNCI NIH HHS P30 CA023074NIAID NIH HHS U19 AI116491NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK083402NIDDK NIH HHS R01 DK118563
Abstract
Tumors evade immune surveillance by expressing Programmed Death-Ligand 1 (PD-L1), subsequently inhibiting CD8
Indexed as
B7-H1 AntigenCD8-Positive T-LymphocytesCells, CulturedHedgehog ProteinsHelicobacter pyloriHumansImmunotherapyOrganoidsSignal TransductionStomach NeoplasmsT-Lymphocytes, CytotoxicTOR Serine-Threonine KinasesTranscription, GeneticTumor MicroenvironmentZinc Finger Protein GLI1B7-H1 AntigenCD274 protein, humanGLI1 protein, humanHedgehog ProteinsMTOR protein, humanTOR Serine-Threonine KinasesZinc Finger Protein GLI1Cytotoxic T lymphocytesMyeloid derived suppressor cellsSonic hedgehogTumor microenvironment
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What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.