ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021
Precision association of lymphatic disease spread with radiation-associated toxicity in oropharyngeal squamous carcinomas.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 15 citations in OpenAlex.
- Lessons from the Development and Deployment of an Interactive Oncological Risk Estimator.... IEEE Workshop on Visual Analytics in Healthcare. IEEE Workshop on Visual Analytics in Healthcare · 2025Article
- FlavorCharter: Development of a Smartphone App for Quantifying Food Flavor.Proceedings ... ICDM workshops. IEEE International Conference on Data Mining · 2025Article
- A Generative Patient Digital Twin for Sequential Treatment of Oropharyngeal Squamous Carcinomas.medRxiv : the preprint server for health sciences · 2025Article
- Dual-Attention BiLSTM for Interpretable Forecasting of Treatment Toxicities.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2025Article
- mEnergy: Development of a Novel mHealth Multi-device Platform for Near Real-time Remote Assessment of Energy Disorders.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- PRO-Based Stratification Improves Model Prediction for Toxicity and Survival of Head and Neck Cancer Patients.IEEE journal of biomedical and health informatics · 2025Article
- DITTO: A Visual Digital Twin for Interventions and Temporal Treatment Outcomes in Head and Neck Cancer.IEEE transactions on visualization and computer graphics · 2025Article
- Determining risk and predictors of head and neck cancer treatment-related lymphedema: A clinicopathologic and dosimetric data mining approach using interpretable machine learning and ensemble feature selection.Clinical and translational radiation oncology · 2024Article
- Roses Have Thorns: Understanding the Downside of Oncological Care Delivery Through Visual Analytics and Sequential Rule Mining.IEEE transactions on visualization and computer graphics · 2024Article
- Predictive Factors for Chemoradiation-Induced Oral Mucositis and Dysphagia in Head and Neck Cancer: A Scoping Review.Cancers · 2023Article
- Spatially-aware clustering improves AJCC-8 risk stratification performance in oropharyngeal carcinomas.Oral oncology · 2023Article
- Investigating Predictive Factors of Dysphagia and Treatment Prolongation in Patients with Oral Cavity or Oropharyngeal Cancer Receiving Radiation Therapy Concurrently with Chemotherapy.Current oncology (Toronto, Ont.) · 2023Article
- Optimal Treatment Selection in Sequential Systemic and Locoregional Therapy of Oropharyngeal Squamous Carcinomas: Deep Q-Learning With a Patient-Physician Digital Twin Dyad.Journal of medical Internet research · 2022Article
- THALIS: Human-Machine Analysis of Longitudinal Symptoms in Cancer Therapy.IEEE transactions on visualization and computer graphics · 2022Article
- Investigating factors associated to dysphagia and need for percutaneous endoscopic gastrostomy in patients with head and neck cancer receiving radiation therapy.Journal of Cancer · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo determine whether patient similarity in terms of head and neck cancer spread through lymph nodes correlates significantly with radiation-associated toxicity. MATERIALS AND
methods582 head and neck cancer patients received radiotherapy for oropharyngeal cancer (OPC) and had non-metastatic affected lymph nodes in the head and neck. Affected lymph nodes were segmented from pretreatment contrast-enhanced tomography scans and categorized according to consensus guidelines. Similar patients were clustered into 4 groups according to a graph-based representation of disease spread through affected lymph nodes. Correlation between dysphagia-associated symptoms and patient groups was calculated.
resultsOut of 582 patients, 26% (152) experienced toxicity during a follow up evaluation 6 months after completion of radiotherapy treatment. Patient groups identified by our approach were significantly correlated with dysphagia, feeding tube, and aspiration toxicity (p < .0005). DISCUSSION: Our results suggest that structural geometry-aware characterization of affected lymph nodes can be used to better predict radiation-associated dysphagia at time of diagnosis, and better inform treatment guidelines.
conclusionOur work successfully stratified a patient cohort into similar groups using a structural geometry, graph-encoding of affected lymph nodes in oropharyngeal cancer patients, that were predictive of late radiation-associated dysphagia and toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.