ArticleEnvironmental toxicology and chemistry2022
A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow.
Article in Environmental toxicology and chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 143 citations in OpenAlex.
- Environmental occurrence, exposure, toxicity, and transformation of benzothiazoles: A review.Eco-Environment & Health · 2026Review
- Metabolic disruption in salmonids following co-exposure to road runoff contaminants 6PPD-Quinone and 9,10-anthraquinone.The Science of the total environment · 2026Article
- Multi-endpoint assessment of tunnel wash water and tyre-particle leachate in zebrafish larvae.Toxicology reports · 2025Article
- Occurrence and environmental fate/behaviors of tire wear particles and their human and ecological health: an emerging global issue.Archives of toxicology · 2025Review
- Aging of Tire Particles in Deep-Sea Conditions: Interactions between Hydrostatic Pressure, Prokaryotic Growth and Chemical Leaching.Environmental science & technology · 2025Article
- Tire Rubber-Derived Cyclic Amines in Urban Ambient Particulate Matter in Shanghai.ACS earth & space chemistry · 2025Article
- Exploiting Molecular Ions for Screening Hydrophobic Contaminants in Sediments Using Gas Chromatography-Atmospheric Pressure Chemical Ionization-Ion Mobility-Mass Spectrometry.Environmental science & technology · 2025Article
- Comparative Toxicity of Micro, Nano, and Leachate Fractions of Three Rubber Materials to Freshwater Species: Zebrafish andMicroplastics (Basel, Switzerland) · 2025Article
- Polyurethane microplastics and associated tris(chloropropyl)phosphate additives both affect development in larval fathead minnow Pimephales promelas.Environmental toxicology and chemistry · 2025Article
- Quantification Approaches in Non-Target LC/ESI/HRMS Analysis: An Interlaboratory Comparison.Analytical chemistry · 2024Article
- Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes.Environmental health perspectives · 2024Article
- Where the rubber meets the road: Emerging environmental impacts of tire wear particles and their chemical cocktails.The Science of the total environment · 2024Review
- Behavioral and molecular effects of micro and nanoplastics across three plastic types in fish: weathered microfibers induce a similar response to nanosized particles.Frontiers in toxicology · 2024Article
- 1,3-Diphenylguanidine, benzothiazole, benzotriazole, and their derivatives in soils collected from northeastern United States.The Science of the total environment · 2023Article
- Determination of 1,3-Diphenylguanidine, 1,3-Di-Environmental science & technology · 2023Article
- Occurrence of 1,3-Diphenylguanidine, 1,3-Di-Environmental science & technology · 2023Article
- Uptake, MetabolismEnvironmental science & technology · 2023Article
- The Minderoo-Monaco Commission on Plastics and Human Health.Annals of global health · 2023Review
- Bioaccessibility of Organic Compounds Associated with Tire Particles Using a FishEnvironmental science & technology · 2022Article
- White Rot Fungi Produce Novel Tire Wear Compound Metabolites and Reveal Underappreciated Amino Acid Conjugation Pathways.Environmental science & technology letters · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ecological impact of tire wear particles in aquatic ecosystems is a growing environmental concern. We combined toxicity testing, using fathead minnow (Pimephales promelas) embryos, with nontarget high-resolution liquid chromatography Orbitrap mass spectrometry to characterize the toxicity and chemical mixture of organic chemicals associated with tire particle leachates. We assessed: 1) exposure to tire particle leachates after leaching for 1-, 3-, and 10-d; and 2) the effect of the presence and absence of small tire particulates in the leachates. We observed a decrease in embryonic heart rates, hatching success, and lengths, as well as an increase in the number of embryos with severe deformities and diminished eye and body pigmentation, after exposure to the leachates. Overall, there was a pattern whereby we observed more toxicity in the 10-d leachates, and greater toxicity in unfiltered leachates. Redundancy analysis showed that several benzothiazoles and aryl-amines were correlated with the toxic effects observed in the embryos. These included benzothiazole, 2-aminobenzothiazole, 2-mercaptobenzothiazole, N,N'-diphenylguanidine, and N,N'-diphenylurea. However, many other chemicals characterized as unknowns are likely to also play a key role in the adverse effects observed. Our study provides insight into the types of chemicals likely to be important toxicological drivers in tire leachates, and improves our understanding of the ecotoxicological impacts of tire wear particles. Environ Toxicol Chem 2022;41:1144-1153. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.