Evidence map›Paper›PMID 34125847›Full record

ArticlePloS one2021

Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.

Xiong Jiang, James H Howard, G William Rebeck, Raymond Scott Turner

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xiong JiangDepartment of Neuroscience, Georgetown University Medical Center, Washington, D.C., United States of America.ORCID 0000-0001-7054-1556
James H HowardDepartment of Psychology, The Catholic University of America, Washington, D.C., United States of America.
G William RebeckDepartment of Neuroscience, Georgetown University Medical Center, Washington, D.C., United States of America.
Raymond Scott TurnerDepartment of Neurology, Georgetown University Medical Center, Washington, D.C., United States of America.
Georgetown University · USUniversity of America · US

Funding

APOE isoform affects protein structure and function in normal brainR01NS100704 · NINDS · GEORGETOWN UNIVERSITY · PI REBECK, G WILLIAM · 2017 to 2021
$2.0M
NINDS NIH HHS R01 NS100704
6 · The paper itself

Abstract

Spatial inhibition of return (IOR) refers to the phenomenon by which individuals are slower to respond to stimuli appearing at a previously cued location compared to un-cued locations. Here with a group of older adults (n = 56, 58-80 (67.9±5.2) year old, 31 females, 18.7±3.6 years of education), we provide evidence supporting the notion that spatial IOR is mildly impaired in individuals with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD), and the impairment is detectable using a double cue paradigm. Furthermore, reduced spatial IOR in high-risk healthy older individuals is associated with reduced memory and other neurocognitive task performance, suggesting that the double cue spatial IOR paradigm may be useful in detecting MCI and early AD.

Indexed as

Inhibition, PsychologicalAgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesCognitive DysfunctionFemaleHumansMaleMiddle AgedNeuropsychological TestsSpace PerceptionUnited StatesVisual Perception

Identifiers

PMID34125847
PMCPMC8202934
OpenAlexW3172382566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.