Evidence map›Paper›PMID 34125846›Full record

ArticlePLoS computational biology2021

Iliski, a software for robust calculation of transfer functions.

Ali-Kemal Aydin, William D Haselden, Julie Dang, Patrick J Drew, Serge Charpak, Davide Boido

Abstract read
In one paragraph

Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ali-Kemal AydinINSERM U1128, Laboratory of Neurophysiology and New Microscopy, Université de Paris, Paris, France.ORCID 0000-0002-3583-6604
William D HaseldenMedical Scientist Training Program and Neuroscience Graduate Program, The Pennsylvania State University, University Park, Pennsylvania, United States of America.ORCID 0000-0001-6542-7505
Julie DangINSERM, CNRS, Institut de la Vision, Sorbonne Université, Paris, France.ORCID 0000-0002-4442-3828
Patrick J DrewDepartments of Engineering Science and Mechanics, Biomedical Engineering, and Neurosurgery, The Pennsylvania State University, University Park, Pennsylvania, United States America.ORCID 0000-0002-7483-7378
Serge CharpakINSERM U1128, Laboratory of Neurophysiology and New Microscopy, Université de Paris, Paris, France.
Davide BoidoINSERM U1128, Laboratory of Neurophysiology and New Microscopy, Université de Paris, Paris, France.ORCID 0000-0002-1823-0555

Funding

Imaging neurovascular coupling and functional connectivity in the behaving mouseR01NS078168 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI DREW, PATRICK JAMES · 2013 to 2023
$3.3M
CRCNS: US-French Research Proposal: Neurovascular coupling-democracy or oligarchy?R01EB021703 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI DREW, PATRICK JAMES · 2015 to 2018
$462k
NIBIB NIH HHS R01 EB021703NINDS NIH HHS R01 NS078168
6 · The paper itself

Abstract

Understanding the relationships between biological processes is paramount to unravel pathophysiological mechanisms. These relationships can be modeled with Transfer Functions (TFs), with no need of a priori hypotheses as to the shape of the transfer function. Here we present Iliski, a software dedicated to TFs computation between two signals. It includes different pre-treatment routines and TF computation processes: deconvolution, deterministic and non-deterministic optimization algorithms that are adapted to disparate datasets. We apply Iliski to data on neurovascular coupling, an ensemble of cellular mechanisms that link neuronal activity to local changes of blood flow, highlighting the software benefits and caveats in the computation and evaluation of TFs. We also propose a workflow that will help users to choose the best computation according to the dataset. Iliski is available under the open-source license CC BY 4.0 on GitHub (https://github.com/alike-aydin/Iliski) and can be used on the most common operating systems, either within the MATLAB environment, or as a standalone application.

Indexed as

SoftwareAlgorithmsComputational BiologyWorkflow

Identifiers

PMID34125846
PMCPMC8224889

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.