Evidence map›Paper›PMID 34125531›Full record

ArticleEnvironmental science & technology2021

Characterization of the Metabolic Pathways of 4-Chlorobiphenyl (PCB3) in HepG2 Cells Using the Metabolite Profiles of Its Hydroxylated Metabolites.

Chun-Yun Zhang, Susanne Flor, Patricia Ruiz, Gabriele Ludewig, Hans-Joachim Lehmler

Open access · hybridAbstract read
In one paragraph

Article in Environmental science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  2. Whole-Body Disposition and Metabolism of [Environmental science & technology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chun-Yun ZhangDepartment of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52242, United States.
Susanne FlorDepartment of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52242, United States.
Patricia RuizOffice of Innovation and Analytics, Simulation Science Section, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30333, United States.
Gabriele LudewigDepartment of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52242, United States.
Hans-Joachim LehmlerDepartment of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52242, United States.ORCID 0000-0001-9163-927X
University of Iowa · USAgency for Toxic Substances and Disease Registry · US

Funding

Training CoreP42ES013661 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 2006 to 2026
$60.3M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
Molecular and Cellular Basis of PCB Developmental Neurotoxicity: ViCTER supplementR01ES014901 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HANS-JOACHIM LEHMLER, Pamela J Lein · 2009 to 2026
$9.3M
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?R01ES031098 · NIEHS · UNIVERSITY OF IOWA · PI CUI, JULIA YUE, LEHMLER, HANS-JOACHIM · 2020 to 2024
$3.1M
PCB Enantiomers Implicated in Neurodevelopmental Disorders: Identification of Individual Metabolic Factors that Determine Risk and VulnerabilityR21ES027169 · NIEHS · UNIVERSITY OF IOWA · PI LEHMLER, HANS-JOACHIM · 2017 to 2018
$410k
Molecular and Cellular Basis of PCB Developmental NeurotoxicityR56ES014901 · NIEHS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEIN, PAMELA J · 2007 to 2007
$150k
NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P42 ES013661NIEHS NIH HHS R01 ES014901NIEHS NIH HHS R01 ES031098NIEHS NIH HHS R21 ES027169NIEHS NIH HHS R56 ES014901
6 · The paper itself

Abstract

The characterization of the metabolism of lower chlorinated PCB, such as 4-chlorobiphenyl (PCB3), is challenging because of the complex metabolite mixtures formed

Indexed as

Biphenyl CompoundsMetabolic Networks and PathwaysHep G2 CellsHumansHydroxylationMass Spectrometry4-chlorobiphenylBiphenyl Compounds4-chlorobiphenylHepG2 cellshydroxylated metabolites

Identifiers

PMID34125531
PMCPMC8264946
OpenAlexW3169423050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.