ReviewJournal of mammary gland biology and neoplasia2021
A Comparative Review of the Cell Biology, Biochemistry, and Genetics of Lactose Synthesis.
Review in Journal of mammary gland biology and neoplasia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A meta-analysis of the effects of sugarcane green waste on productivity, carcass characteristics, meat quality, and milk production in sheep.Tropical animal health and production · 2025Pooled it
- Conventional Culture Conditions Limit the Ability of Bovine Mammary Epithelial Cells to Produce Milk Fat.Foods (Basel, Switzerland) · 2026Article
- Thiamine modulates the mammary inflammation, antioxidant function and lactation performance in lactating sheep under heat-stress conditions.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Assessing the Feasibility of Mid- and Near-Infrared Spectroscopy for Classifying Plant-Based Beverages and Predicting Nutrient Content.Foods (Basel, Switzerland) · 2026Article
- Strategies for GH functional annotation: toward harmonized and predictive CAZymology.Biotechnology for biofuels and bioproducts · 2026Article
- Balancing High Yield and Metabolic Health in Dairy Ruminants: The Central Hub Role of the Rumen Microbiota.Veterinary sciences · 2026Review
- Analytical validation of an advanced U-HPLC-MS/MS method for lactose detection in food supplements and pharmaceuticals.Analytical and bioanalytical chemistry · 2026Article
- Expression Patterns of LALBA and Nucleolin and Their Clinical, Prognostic, and Immune Relevance in Breast Cancer Tissues of Mexican Patients.International journal of molecular sciences · 2026Article
- Article
- Preterm infant formulas with glucose polymers and reduced lactose content increase the risk of necrotizing enterocolitis.Frontiers in nutrition · 2026Review
- Article
- Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation.Nature communications · 2025Article
- Reference Values for Macronutrients in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study.Advances in nutrition (Bethesda, Md.) · 2025Article
- Breastfeeding in Mothers With Type 1 Diabetes: Impact of Maternal Glycemia on Breast Milk Composition.Diabetes care · 2025Article
- Genome-wide study for signatures of selection identifies genomic regions and candidate genes associated with milk traits in sheep.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Article
- Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing.Frontiers in molecular biosciences · 2025Review
- Use of Precision Feeding during Lactation Improves the Productive Yields of Sows and Their Piglets under Commercial Farm Conditions.Animals : an open access journal from MDPI · 2024Article
- Heat stress affects mammary metabolism by influencing the plasma flow to the glands.Journal of animal science and biotechnology · 2024Article
- Human Milk Oligosaccharides in Maternal Serum Respond to Oral Glucose Load and Are Associated with Insulin Sensitivity.Nutrients · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Lactose is the primary carbohydrate in the milk of most mammals and is unique in that it is only synthesized by epithelial cells in the mammary glands. Lactose is also essential for the development and nutrition of infants. Across species, the concentration of lactose in milk holds a strong positive correlation with overall milk volume. Additionally, there is a range of examples where the onset of lactose synthesis as well as the content of lactose in milk varies between species and throughout a lactation. Despite this diversity, the precursors, genes, proteins and ions that regulate lactose synthesis have not received the depth of study they likely deserve relative to the significance of this simple and abundant molecule. Through this review, our objective is to highlight the requirements for lactose synthesis at the biochemical, cellular and temporal levels through a comparative approach. This overview also serves as the prelude to a companion review describing the dietary, hormonal, molecular, and genetic factors that regulate lactose synthesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.