ReviewJournal of mammary gland biology and neoplasia2021
A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis.
Review in Journal of mammary gland biology and neoplasia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Effects of Mare Age and Number of Foalings on Body Morphometry, Udder Morphology, Milk Yield, and Milk Composition in Kushum Mares.Animals : an open access journal from MDPI · 2026Article
- Proteomic insights into goat milk serum proteins at varying altitudes in China.Food chemistry: X · 2026Article
- Short-term modulation of human milk oligosaccharides in plasma and milk by glucose and insulin: insights into postpartum metabolic regulation.Diabetologia · 2026Article
- Expression Patterns of LALBA and Nucleolin and Their Clinical, Prognostic, and Immune Relevance in Breast Cancer Tissues of Mexican Patients.International journal of molecular sciences · 2026Article
- Lipidomics-Based Analysis of the Regulatory Effects of Phytosterol Esters on Lactation Performance and Lipid Metabolism in TarimAnimals : an open access journal from MDPI · 2025Article
- Effects of hypoxia stress on the milk synthesis in bovine mammary epithelial cells.Journal of animal science and biotechnology · 2025Article
- Milk Composition Is Predictive of Low Milk Supply Using Machine Learning Approaches.Diagnostics (Basel, Switzerland) · 2025Article
- Mammary fat globules as a source of mRNA to model alterations in the expression of some milk component genes during lactation in bovines.BMC veterinary research · 2024Article
- Changes in the metabolomic profiles of mammary secretion in relation to dam litter size and parity number in Black Bengal goats.Veterinary world · 2024Article
- Combined Metabolomics and Biochemical Analyses of Serum and Milk Revealed Parity-Related Metabolic Differences in Sanhe Dairy Cattle.Metabolites · 2024Article
- Metabolic Changes in Serum and Milk of Holstein Cows in Their First to Fourth Parity Revealed by Biochemical Analysis and Untargeted Metabolomics.Animals : an open access journal from MDPI · 2024Article
- Seasonal Changes in the Antioxidant Activity and Biochemical Parameters of Goat Milk.Animals : an open access journal from MDPI · 2023Article
- High Expression Level of α2-3-Linked Sialic Acids on Salivary Glycoproteins of Breastfeeding Women May Help to Protect Them from Avian Influenza Virus Infection.Molecules (Basel, Switzerland) · 2022Article
- Transcriptomic changes underlying glucocorticoid-induced suppression of milk production by dairy cows.Frontiers in genetics · 2022Article
- A Comparative Review of the Cell Biology, Biochemistry, and Genetics of Lactose Synthesis.Journal of mammary gland biology and neoplasia · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Milk is critical for the survival of all mammalian offspring, where its production by a mammary gland is also positively associated with its lactose concentration. A clearer understanding of the factors that regulate lactose synthesis stands to direct strategies for improving neonatal health while also highlighting opportunities to manipulate and improve milk production and composition. In this review we draw a cross-species comparison of the extra- and intramammary factors that regulate lactose synthesis, with a special focus on humans, dairy animals, and rodents. We outline the various factors known to influence lactose synthesis including diet, hormones, and substrate supply, as well as the intracellular molecular and genetic mechanisms. We also discuss the strengths and limitations of various in vivo and in vitro systems for the study of lactose synthesis, which remains an important research gap.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.