Evidence map›Paper›PMID 34125343›Full record

ArticleEuropean journal of epidemiology2021

Estimating the hazard rate difference from case-cohort studies.

Jie K Hu, Kwun C G Chan, David J Couper, Norman E Breslow

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jie K HuDepartment of Biostatistics, University of Washington, Seattle, WA, 98105, USA. contact@katehu.com.ORCID http://orcid.org/0000-0002-7987-8419
Kwun C G ChanDepartment of Biostatistics, University of Washington, Seattle, WA, 98105, USA.
David J CouperUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Norman E BreslowDepartment of Biostatistics, University of Washington, Seattle, WA, 98105, USA.
University of Washington · USUniversity of North Carolina at Chapel Hill · US

Funding

Methods of reduced-cost designs for studying disease incidence and fatality risksR01HL122212 · NHLBI · UNIVERSITY OF WASHINGTON · PI CHAN, KWUN CHUEN GARY · 2014 to 2017
$2.2M
NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL122212
6 · The paper itself

Abstract

The case-cohort design, among many two-phase sampling designs, substantially reduces the cost of an epidemiological study by selecting more informative participants within the full cohort for expensive variable measurements. Despite their benefits, additive hazards models, which estimate hazard differences, have rarely been used for the analysis of case-cohort studies due to the lack of software and application examples. In this paper, we describe a newly developed estimation method that fits the additive hazards models to general two-phase sampling studies along with the R package addhazard that implements it. It allows for missing covariates among cases, cohort stratification, robust variances, and the incorporation of auxiliary information from the full cohort to enhance inference precision. We demonstrate the use of this tool to estimate the association of the risk of coronary heart disease (CHD) with biomarkers high-sensitivity C-reactive protein (hs-CRP) and Lipoprotein-associated phospholipase A

Indexed as

1-Alkyl-2-acetylglycerophosphocholine EsteraseCoronary DiseaseBiomarkersCohort StudiesC-Reactive ProteinHumans1-Alkyl-2-acetylglycerophosphocholine EsteraseBiomarkersC-Reactive ProteinAdditive hazards modelsAuxiliary variablesCase cohort studyHazard differencehs-CRPLp-PLA2

Identifiers

PMID34125343
PMCPMC12001820
OpenAlexW3172458344

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.