ArticleAnnals of intensive care2021
Prevalence and risk factors of hemodynamic instability associated with preload-dependence during continuous renal replacement therapy in a prospective observational cohort of critically ill patients.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Prevalence of cardiovascular instability during hemodialysis therapy in hospitalized patients: A systematic review and meta-analysis.Science progressPooled it
- Factors associated with adverse haemodynamic events during the STARRT-AKI trial: a post-hoc secondary analysis.Critical care (London, England) · 2025Trial
- Diagnostic performance of a 250-ml net ultrafiltration challenge to identify risk of preload-dependence in critically ill patients undergoing continuous renal replacement therapy: a randomized, cross-over trial.Critical care (London, England) · 2025Trial
- Fluid balance neutralization secured by hemodynamic monitoring versus protocolized standard of care in patients with acute circulatory failure requiring continuous renal replacement therapy: results of the GO NEUTRAL randomized controlled trial.Intensive care medicine · 2024Trial
- The Fluid Overload Ultrafiltration Percentage (FOUP): a novel metric that contextualizes fluid removal to initial burden in pediatric CRRT.Pediatric research · 2026Article
- Ultrafiltration in the critically ill patient: a framework for personalized care.Critical care (London, England) · 2026Review
- Specialized nursing improves clinical outcomes in pediatric AKI patients undergoing CRRT: a retrospective cohort study.American journal of translational research · 2026Article
- Extracorporeal circuit temperature gradient and hemodynamic instability during continuous renal replacement therapy: an observational study.Annals of intensive care · 2026Article
- Systolic blood pressure time in target range within 24 h and in-hospital death of critically ill patients and the role of ventricular arrhythmias: a MIMIC-IV analysis with external validation in the eICU-CRD database.European journal of medical research · 2025Article
- The value of transpulmonary thermodilution parameters in predicting hemodynamic instability in intensive care patients undergoing continuous renal replacement therapy.BMC nephrology · 2025Observational
- Comparison of the efficacy and safety of Landiolol and Esmolol in critically ill patients: a propensity score-matched study.Annals of intensive care · 2025Article
- Observational
- Predictors of intradialytic hypotension in critically ill patients undergoing kidney replacement therapy: a systematic review.Intensive care medicine experimental · 2024Review
- Predicting intradialytic hypotension in critically ill patients undergoing intermittent hemodialysis: a prospective observational study.Intensive care medicine experimental · 2024Article
- Article
- Syndecan-1 predicts hemodynamic instability in critically ill patients under intermittent hemodialysis.Clinical kidney journal · 2023Article
- Article
- Hemodynamic Monitoring in Sepsis-A Conceptual Framework of Macro- and Microcirculatory Alterations.Diagnostics (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHemodynamic instability is a frequent complication of continuous renal replacement therapy (CRRT). Postural tests (i.e., passive leg raising in the supine position or Trendelenburg maneuver in the prone position) combined with measurement of cardiac output are highly reliable to identify preload-dependence and may provide new insights into the mechanisms involved in hemodynamic instability related to CRRT (HIRRT). We aimed to assess the prevalence and risk factors of HIRRT associated with preload-dependence in ICU patients. We conducted a single-center prospective observational cohort study in ICU patients with acute kidney injury KDIGO 3, started on CRRT in the last 24 h, and monitored with a PiCCO® device. The primary endpoint was the rate of HIRRT episodes associated with preload-dependence during the first 7 days after inclusion. HIRRT was defined as the occurrence of a mean arterial pressure below 65 mmHg requiring therapeutic intervention. Preload-dependence was assessed by postural tests every 4 h, and during each HIRRT episode. Data are expressed in median [1st quartile-3rd quartile], unless stated otherwise.
results42 patients (62% male, age 69 [59-77] year, SAPS-2 65 [49-76]) were included 6 [1-16] h after CRRT initiation and studied continuously for 121 [60-147] h. A median of 5 [3-8] HIRRT episodes occurred per patient, for a pooled total of 243 episodes. 131 episodes (54% [CI
conclusionsIn this single-center study, HIRRT associated with preload-dependence was slightly more frequent than HIRRT without preload-dependence in ICU patients undergoing CRRT. Testing for preload-dependence could help avoiding unnecessary decrease of fluid removal in preload-independent HIRRT during CRRT.
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