Evidence map›Paper›PMID 34124995›Full record

ArticleHuman vaccines & immunotherapeutics2021

The epidemiology, diagnosis and management of scrub typhus disease in China.

Taha Hussein Musa, Tauseef Ahmad, Mohammed Nasiru Wana, Wei Li, Hassan Hussein Musa, Khan Sharun, Ruchi Tiwari, Kuldeep Dhama, Wanpen Chaicumpa, Michael C Campbell and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Analysis of the Epidemiological Characteristics and Risk Factors for Severe Progression of Scrub Typhus in the Dali Region of China.Medical science monitor : international medical journal of experimental and clinical research · 2026
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  9. Eschar is not the sole clue for scrub typhus: a retrospective analysis of pediatric scrub typhus without eschars.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
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  10. Ningxia First Case ofChina CDC weekly · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 6 countries.

Taha Hussein MusaKey Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Tauseef AhmadKey Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.ORCID 0000-0001-8793-273X
Mohammed Nasiru WanaDepartment of Biological Sciences, Faculty of Science, Abubakar Tafawa Balewa University, Bauchi, Nigeria.
Wei LiKey Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Hassan Hussein MusaFaculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Khan SharunDivision of Surgery, ICAR-Indian Veterinary Research Institute, Bareilly, India.ORCID 0000-0003-1040-3746
Ruchi TiwariDepartment of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Deen Dayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, India.ORCID 0000-0001-6897-3472
Kuldeep DhamaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India.ORCID 0000-0001-7469-4752
Wanpen ChaicumpaCenter of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Michael C CampbellDepartment of Biology, Howard University, Washington, DC, USA.
Pingmin WeiKey Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Southeast University · CNIndian Veterinary Research Institute · INAbubakar Tafawa Balewa University · NGHoward University · USSiriraj Hospital · THUniversity of Khartoum · SDUttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thirty-nine years ago, scrub typhus (ST), a disease, was not among the China's notifiable diseases. However, ST has reemerged to become a growing public health issue in the southwest part of China. The major factors contributing to an increased incidence and prevalence of this disease include rapid globalization, urbanization, expansion of humans into previously uninhabited areas, and climate change. The clinical manifestation of ST also consists of high fever, headache, weakness, myalgia, rash, and an eschar. In severe cases, complications (e.g. multi-organ failure, jaundice, acute renal failure, pneumonitis, myocarditis, and even death) can occur. The diagnosis of ST is mainly based on serological identification by indirect immunofluorescence assay and other molecular methods. Furthermore, several groups of antibiotics (e.g. tetracycline, chloramphenicol, macrolides, and rifampicin) are currently effective in treating this disease. This fact suggests the need for robust early diagnostic techniques, increased surveillance, and prompt treatment, and develop future vaccine.

Indexed as

Orientia tsutsugamushiScrub TyphusAnti-Bacterial AgentsChinaFluorescent Antibody Technique, IndirectHumansAnti-Bacterial AgentschinadiagnosisOrientia tsutsugamushiprevalenceScrub typhus

Identifiers

PMID34124995
PMCPMC8437466
OpenAlexW3191290399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.