Evidence map›Paper›PMID 34124945›Full record

ArticleJournal of bacteriology2021

Topoisomerase I Essentiality, DnaA-Independent Chromosomal Replication, and Transcription-Replication Conflict in Escherichia coli.

J Krishna Leela, Nalini Raghunathan, J Gowrishankar

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
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  4. Bacterial Topoisomerase I Growth Complementation Assay.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

J Krishna LeelaLaboratory of Bacterial Genetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
Nalini RaghunathanLaboratory of Bacterial Genetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
J GowrishankarLaboratory of Bacterial Genetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
Centre for DNA Fingerprinting and Diagnostics · INIndian Institute of Science Education and Research Mohali · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Topoisomerase I (Topo I) of Escherichia coli, encoded by

Indexed as

Transcription, GeneticBacterial ProteinsChromosomes, BacterialDNA, BacterialDNA-Binding ProteinsDNA ReplicationDNA Topoisomerases, Type IEscherichia coliGenome, BacterialBacterial ProteinsDnaA protein, BacteriaDNA, BacterialDNA-Binding ProteinsDNA Topoisomerases, Type Iconstitutive stable DNA replicationDNA supercoilingR loopstopoisomerase Itranscription-replication conflict

Identifiers

PMID34124945
PMCPMC8351630
OpenAlexW3171090791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.