Evidence map›Paper›PMID 34124942›Full record

ArticleJournal of bacteriology2021

The ChvG-ChvI and NtrY-NtrX Two-Component Systems Coordinately Regulate Growth of Caulobacter crescentus.

Benjamin J Stein, Aretha Fiebig, Sean Crosson

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. An N4-likeJournal of bacteriology · 2026
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  5. An N4-likebioRxiv : the preprint server for biology · 2025
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  14. Transcriptomic response ofFrontiers in microbiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Benjamin J SteinDepartment of Microbiology and Molecular Genetics, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Aretha FiebigDepartment of Microbiology and Molecular Genetics, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Sean CrossonDepartment of Microbiology and Molecular Genetics, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Michigan State University · US

Funding

Molecular mechanisms controlling stress responses and cell adhesion in bacteriaR35GM131762 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Sean Crosson · 2019 to 2026
$3.2M
Elucidating the mechanism and sensory properties of a novel iron-sulfur binding histidine kinase inhibitorF32GM128283 · NIGMS · UNIVERSITY OF CHICAGO · PI STEIN, BENJAMIN J · 2018 to 2019
$123k
NIGMS NIH HHS F32 GM128283NIGMS NIH HHS R35 GM131762
6 · The paper itself

Abstract

Two-component signaling systems (TCSs) are comprised of a sensory histidine kinase and a response regulator protein. In response to environmental changes, sensor kinases directly phosphorylate their cognate response regulator to affect gene expression. Bacteria typically express multiple TCSs that are insulated from one another and regulate distinct physiological processes. There are examples of cross-regulation between TCSs, but this phenomenon remains relatively unexplored. We have identified regulatory links between the ChvG-ChvI (ChvGI) and NtrY-NtrX (NtrYX) TCSs, which control important and often overlapping processes in alphaproteobacteria, including maintenance of the cell envelope. Deletion of

Indexed as

Gene Expression Regulation, BacterialBacterial ProteinsCaulobacter crescentusPhosphorylationRegulonSignal TransductionBacterial ProteinsCaulobacter crescentuscell envelopeChvGChvIChvThistidine kinaseNtrXNtrYresponse regulatortwo-component regulatory systems

Identifiers

PMID34124942
PMCPMC8351639
OpenAlexW3169446109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.