Evidence map›Paper›PMID 34124861›Full record

ArticleBrain and behavior2021

Psychometric properties of a patient-reported outcome set in acute stroke patients.

Rebecca Philipp, Lisa Lebherz, Götz Thomalla, Martin Härter, Hannes Appelbohm, Marc Frese, Levente Kriston

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Quality of life measures for people following stroke: a structured content review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Review
  2. Article
  3. Psychometric properties and general population reference values for PROMIS Global Health in Hungary.The European journal of health economics : HEPAC : health economics in prevention and care · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rebecca PhilippDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-1875-3823
Lisa LebherzDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Götz ThomallaDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-4785-1449
Martin HärterDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-7443-9890
Hannes AppelbohmDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marc FreseOffice for Quality Management and Clinical Process Management, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Levente KristonDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-0748-264X
Universität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesImpairments after stroke may affect multiple domains of health-related quality of life (HRQoL). Patient-reported outcome measures (PROMs) have proven valuable in measuring patients' well-being. We examine the psychometric properties of a standard set of PROMs assessing global health, anxiety, and depression, and functioning in a German health care setting.

methodWe included inpatients at the Department of Neurology at the University Medical Center Hamburg-Eppendorf, diagnosed with stroke. Following the stroke-specific standard set of the International Consortium for Health Outcome Measurement, we collected demographic and clinical information at baseline, and PROMs for global health (PROMIS-10), three items for self-reported functioning, anxiety, and depression (PHQ-4) at 90 days follow-up. We calculated confirmatory factor analyses to test factorial validity and correlation analyses to test construct validity. We further conducted item and reliability analyses.

resultsIn a sample of 487 patients (mean age, SD: 71.1, 12.6; 47% female) with mild and moderate symptoms, model fit for the PROMIS-10 was acceptable for the two-factor and single-factor models. Factor loadings ranged from 0.52 to 0.94. The postulated single-factor model for functioning was saturated with zero degrees of freedom. Factor loadings ranged from 0.90 to 0.96. For the PHQ-4, the two-factor model showed excellent model fit. Factor loadings ranged from 0.78 to 0.87. Internal consistency was acceptable to good. Construct validity was generally confirmed.

conclusionsThe PROMIS-10 is a valid and reliable instrument to measure HRQoL among German stroke patients. While the PHQ-4 was confirmed as a screening measure for mental disorders, further research is needed on items assessing self-reported functioning. Results are limited to patients showing minimal functional deficits.

Indexed as

Quality of LifeStrokeFemaleHumansMalePatient Reported Outcome MeasuresPsychometricsReproducibility of ResultsSurveys and QuestionnairesICHOMpatient-reported outcome measuresPROMISpsychometric propertiesstrokevalidation

Identifiers

PMID34124861
PMCPMC8413767
OpenAlexW3169272363

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.