ArticleBrain and behavior2021
Brain functional changes in patients with Crohn's disease: A resting-state fMRI study.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Mapping the neuroimaging landscape of inflammatory bowel disease: a bibliometric analysis and systematic scoping review.Frontiers in neuroscience · 2026Pooled it
- Altered resting-state brain functional activities and networks in Crohn's disease: a systematic review.Frontiers in neuroscience · 2024Pooled it
- Altered resting-state brain activity in functional dyspepsia patients: a coordinate-based meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Shared and distinct spontaneous brain activity pattern in crohn's disease and ulcerative colitis: evidence from cortical surface‑based analysis.BMC gastroenterology · 2026Article
- A Heavy Feeling in the Stomach: Neural Correlates of Anxiety in Crohn's Disease.Neurogastroenterology and motility · 2025Article
- Differential Association Between Default Mode Network Connectivity and Attachment Styles in Healthy Individuals and Crohn's Disease Patients.Brain and behavior · 2025Article
- Current approaches to studying human resting-state function in inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2025Article
- Review study of alteration functional activities and networks in ulcerative colitis using resting-state fMRI.Frontiers in neurology · 2025Review
- Neurofunctional correlates of emotional dysregulation in adolescent Crohn's disease: a resting-state fMRI preliminary investigation.Frontiers in neuroscience · 2025Article
- Multi-network dynamical structure of the human brain in the setting of chronic pain: a coordinate-based meta-analysis.Brain communications · 2025Article
- Evaluation of neostriatum changes in Crohn's disease: a multimodal brain magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2024Article
- Identification of neural alterations in patients with Crohn's disease with a novel multiparametric brain MRI-based radiomics model.Insights into imaging · 2024Article
- Disease-specific alterations in central fear network engagement during acquisition and extinction of conditioned interoceptive fear in inflammatory bowel disease.Molecular psychiatry · 2024Article
- Evidence linking gut-brain axis and Crohn's disease, focusing on neurotrophic dysfunctions and radiological imaging analysis - a systematic review.American journal of translational research · 2024Article
- Preliminary study on early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice using multimodal magnetic resonance imaging.Frontiers in aging neuroscience · 2024Article
- A potential brain functional biomarker distinguishing patients with Crohn's disease with different disease stages: a resting-state fMRI study.Frontiers in neuroscience · 2024Article
- The relationship between Central Nervous System morphometry changes and key symptoms in Crohn's disease.Brain imaging and behavior · 2023Article
- The involvement of spontaneous brain activity in natural recovery from internet gaming disorder: A resting-state fMRI study.Frontiers in psychiatry · 2023Article
- Altered intrinsic functional brain architecture in patients with functional constipation: a surface-based network study.Frontiers in neuroscience · 2023Article
- Inflammatory bowel diseases, interleukin-6 and interleukin-6 receptor subunit alpha in causal association with cerebral cortical structure: a Mendelian randomization analysis.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrohn's disease (CD) is a chronic recurrent intestinal inflammatory disease, often accompanied by poor adaptation and excessive stress response. However, the potential neurological mechanisms of these symptoms have not yet been studied in-depth.
objectiveTo investigate alterations in brain activity in patients with Crohn's disease and study the relationship between altered regions and clinical indices.
methodsA total of 15 CD patients and 26 matched healthy controls were recruited. All participants underwent fMRI scans. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) assessed differences in spontaneous regional brain activity. Differences between the groups were selected as seeds for functional connectivity (FC) analyses. Correlations between disease duration and ALFF/ReHo/FC values in abnormal regions were analyzed.
resultsPatients with CD had significantly higher ALFF values in the left superior frontal gyrus, anterior cingulate cortex, and supplementary motor area, and lower values in the left hippocampus. They also had higher ReHo values in the left anterior cingulate cortex, supplementary motor area, putamen, and the bilateral superior frontal gyri. FC strength in the left precentral and middle temporal gyri was found to be increased when the left superior frontal gyrus was used as the seed point. FC strength was also observed to be increased in the left postcentral, middle frontal gyri, inferior frontal orbital cortex, and right rolandic operculum when the left anterior cingulate cortex was used as the seed point.
conclusionCD demonstrated abnormal neural activity and FC in various regions primarily associated with emotional, pain and cognitive-related functions, which provides more information to further understand the neural mechanisms of the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.