Evidence map›Paper›PMID 34124856›Full record

Trial reportObesity (Silver Spring, Md.)2021

Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial.

Kaja Falkenhain, Sean R Locke, Dylan A Lowe, Nicholas J Reitsma, Terry Lee, Joel Singer, Ethan J Weiss, Jonathan P Little

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07430618 (Real-World Durability of Weight Loss With a Breath Biofeedback mHealth Program), which is not on this map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07430618 completednot on this map

Real-World Durability of Weight Loss With a Breath Biofeedback mHealth Program: Two-Year Outcomes in Adults With Overweight or Obesity

TypeobservationalSponsorUniversity of British ColumbiaRan2018 to 2025Enrolled11,524ConditionsOverweight (BMI > 25), Obesity (Body Mass Index >30 kg/m2), Obesity & OverweightArmsBreath acetone biofeedback device with mHealth program
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kaja FalkenhainSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.ORCID 0000-0002-3240-964X
Sean R LockeSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Dylan A LoweCardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.
Nicholas J ReitsmaSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Terry LeeCentre for Health Evaluation and Outcome Sciences, School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Joel SingerCentre for Health Evaluation and Outcome Sciences, School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Ethan J WeissCardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-9936-5816
Jonathan P LittleSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.ORCID 0000-0002-9796-2008
University of British Columbia · CAUniversity of California, San Francisco · US

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
CIHR MSH-141980NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

objectiveThe aim of this study was to determine whether a Mediterranean-style, ketogenic diet mobile health application (app) with breath acetone biofeedback is superior to a calorie-restricted, low-fat diet app in promoting weight loss.

methodsParticipants (n = 155) with overweight/obesity (mean [SD]: age 41 [11] years, BMI = 34 [5] kg/m

resultsWeight loss at 12 weeks was greater in the ketogenic (-5.6 kg; 95% CI: -6.7 kg to -4.5 kg) compared with the low-fat group (-2.5 kg; 95% CI: -3.6 kg to -1.4 kg) (between-group difference: -3.1 kg; 95% CI: -4.6 kg to -1.5 kg; p < 0.001). Weight loss at 24 weeks indicated durability of the effect (between-group difference: -5.5 kg; 95% CI: -8.3 kg to -2.8 kg; p < 0.001). Secondary/exploratory outcomes of hemoglobin A1c and liver enzymes were improved to a greater extent in the ketogenic diet group (p < 0.01).

conclusionsAmong adults with overweight/obesity, a ketogenic diet app with breath acetone biofeedback was superior to a calorie-restricted diet app at promoting weight loss in a real-world setting.

Indexed as

Mobile ApplicationsOverweightAdultFemaleGlycated HemoglobinHumansMaleObesityWeight LossGlycated Hemoglobin

Identifiers

PMID34124856
PMCPMC8518592
OpenAlexW3167569358

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.