Evidence map›Paper›PMID 34124841›Full record

ArticleOrthopaedic surgery2021

The Clinical Effect of a Combination of Mouse Nerve Growth Factor and Methylcobalamin to Treat Lumbar Disc Herniation with Foot Drop: A Retrospective Cohort Study.

Zhuang Chen-Yang, Hu An-Nan, Jiang Yun-Qi, Wang Hui-Ren, Li Xi-Lei, Zhou Xiao-Gang, Lin Hong

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Molecular approaches for spinal cord injury treatment.Neural regeneration research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhuang Chen-YangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4866-8750
Hu An-NanDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiang Yun-QiDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Wang Hui-RenDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Li Xi-LeiDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhou Xiao-GangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Lin HongDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Fudan University · CN

Funding

Program for Outstanding Medical Academic Leader of Shanghai LJ10017Shanghai International Science and Technology 11540702700
6 · The paper itself

Abstract

objectiveTo investigate the clinical effect of mouse nerve growth factor (mNGF) and methylcobalamin (MeCbl) for the treatment of lumbar disk herniation (LDH) with foot drop.

methodsA total of 46 patients suffering from LDH with foot drop who underwent transforaminal lumbar interbody fusion (TLIF) surgery in our department from January 2015 to December 2017 were retrospectively analyzed. We divided these patients into two groups according to the different postoperative treatment which independently selected by patients after signing informed consent form: one group of 25 patients was treated with MeCbl alone (Group MeCbl), the other group of 21 patients was treated with a combination of mNGF and MeCbl (Group MeCbl+mNGF). Patient demographics, the visual analogue scale (VAS) scores, sensory and muscular strength improvement statistics at 1 week, 4 weeks, 12 weeks, and 12 months postoperatively were recorded. Motor/sensory deficits, sciatica and overall neurological outcome after treatment of MeCbl alone and combination of mNGF and MeCbl were retrospectively analyzed.

resultsThe follow-up ranged between 12 and 42 months (mean 20.8 months). There were no significant differences between these two groups of patients with respect to sex ratio, age, smoking, diabetes, disease course, section of protruding disc(s), muscular strength of foot dorsiflexion or preoperative visual analogue scale (VAS) score (P > 0.05). The VAS scores of Group MeCbl+mNGF were significantly lower than Group MeCbl at 1 week, 4 weeks, 12 weeks, and 12 months postoperatively (4.32 ± 0.75 vs 5.25 ± 0.79,2.65 ± 0.48 vs 3.42 ± 0.52, 1.72 ± 0.36 vs 2.45 ± 0.39, 1.12 ± 0.22 vs 1.52 ± 0.24, P < 0.05). The effective rates of sensory improvement were significantly higher in Group MeCbl+mNGF compared with Group MeCbl at 12-week/12-month follow-up time point (90.48% vs 52.00%,95.24% vs 68.00%, P < 0.05). The effective rate of muscular strength improvement of the two groups did not differ significantly at 1 week after surgery but exhibited statistically significant differences at subsequent time points (61.90% vs 32.00%, 76.19% vs 44.00%, 80.95% vs 48.00%, P < 0.05).

conclusionsApplication of mNGF had clinical effects on promoting the recovery of neurological function in patients suffering from LDH with foot drop.

Indexed as

AdultAnimalsCohort StudiesCombined Modality TherapyFemaleHumansIntervertebral Disc DisplacementLumbar VertebraeMaleMiceMiddle AgedNerve Tissue ProteinsPain MeasurementPeroneal NeuropathiesPostoperative PeriodReceptors, Growth FactormecobalaminNerve Tissue ProteinsNgfr protein, ratReceptors, Growth FactorVitamin B 12Foot dropLumbar disc herniationMethylcobalaminMouse nerve growth factor

Identifiers

PMID34124841
PMCPMC8313174
OpenAlexW3172988437

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.