Evidence map›Paper›PMID 34124714›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Virologic features of SARS-CoV-2 infection in children.

Lael M Yonker, Julie Boucau, James Regan, Manish C Choudhary, Madeleine D Burns, Nicola Young, Eva J Farkas, Jameson P Davis, Peter P Moschovis, T Bernard Kinane and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 20 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Lael M YonkerMassachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Julie BoucauRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
James ReganBrigham and Women's Hospital, Department of Medicine, Boston, MA, USA.
Manish C ChoudharyHarvard Medical School, Boston, MA, USA.
Madeleine D BurnsMassachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Nicola YoungMassachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Eva J FarkasMassachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Jameson P DavisMassachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Peter P MoschovisMassachusetts General Hospital, Department of Pediatrics, Boston, MA, USA.
T Bernard KinaneMassachusetts General Hospital, Department of Pediatrics, Boston, MA, USA.
Alessio FasanoMassachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Anne M NeilanMassachusetts General Hospital, Department of Pediatrics, Boston, MA, USA.
Jonathan Z LiHarvard Medical School, Boston, MA, USA.
Amy K BarczakHarvard Medical School, Boston, MA, USA.
Harvard University · USMassachusetts General Hospital · USBrigham and Women's Hospital · USRagon Institute of MGH, MIT and Harvard · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
The effect of household air pollution on lung function growth in infants with pneumonia in sub-Saharan Africa.K23ES030399 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSCHOVIS, PETER P · 2019 to 2024
$1.1M
Mechanistically Disentangling the Infected, Inflamed LungK08HL143183 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI YONKER, LAEL · 2018 to 2022
$869k
NHLBI NIH HHS K08 HL143183NIAID NIH HHS P30 AI060354NIEHS NIH HHS K23 ES030399
6 · The paper itself

Abstract

backgroundData on pediatric COVID-19 has lagged behind adults throughout the pandemic. An understanding of SARS-CoV-2 viral dynamics in children would enable data-driven public health guidance.

methodsRespiratory swabs were collected from children with COVID-19. Viral load was quantified by RT-PCR; viral culture was assessed by direct observation of cytopathic effects and semiquantitative viral titers. Correlations with age, symptom duration, and disease severity were analyzed. SARS-CoV-2 whole genome sequences were compared with contemporaneous sequences.

results110 children with COVID-19 (median age 10 years, range 2 weeks-21 years) were included in this study. Age did not impact SARS-CoV-2 viral load. Children were most infectious within the first five days of illness, and severe disease did not correlate with increased viral loads. Pediatric SARS-CoV-2 sequences were representative of those in the community and novel variants were identified.

conclusionsSymptomatic and asymptomatic children can carry high quantities of live, replicating SARS-CoV-2, creating a potential reservoir for transmission and evolution of genetic variants. As guidance around social distancing and masking evolves following vaccine uptake in older populations, a clear understanding of SARS-CoV-2 infection dynamics in children is critical for rational development of public health policies and vaccination strategies to mitigate the impact of COVID-19.

Indexed as

Pediatric COVID-19SARS-CoV-2Viral dynamics

Identifiers

PMID34124714
PMCPMC8193793
OpenAlexW3164367863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.