Evidence map›Paper›PMID 34124675›Full record

ArticleRSC medicinal chemistry2021

New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells.

Elvar Örn Viktorsson, Reidun Aesoy, Sindre Støa, Viola Lekve, Stein Ove Døskeland, Lars Herfindal, Pål Rongved

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Elvar Örn ViktorssonSchool of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo PO Box 1068 Blindern N0316 Oslo Norway pal.rongved@farmasi.uio.no.ORCID https://orcid.org/0000-0002-3585-0561
Reidun AesoyCentre for Pharmacy, Department of Clinical Science, University of Bergen Jonas Lies vei 87 N-5021 Bergen Norway.
Sindre StøaSchool of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo PO Box 1068 Blindern N0316 Oslo Norway pal.rongved@farmasi.uio.no.
Viola LekveCentre for Pharmacy, Department of Clinical Science, University of Bergen Jonas Lies vei 87 N-5021 Bergen Norway.ORCID https://orcid.org/0000-0001-7342-3854
Stein Ove DøskelandDepartment of Biomedicine, University of Bergen Jonas Lies vei 91 N-5021 Bergen Norway.
Lars HerfindalCentre for Pharmacy, Department of Clinical Science, University of Bergen Jonas Lies vei 87 N-5021 Bergen Norway.
Pål RongvedSchool of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo PO Box 1068 Blindern N0316 Oslo Norway pal.rongved@farmasi.uio.no.
University of Bergen · NOUniversity of Oslo · NOUniversity of Iceland · IS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (

Identifiers

PMID34124675
PMCPMC8152588
OpenAlexW3155399523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.