ReviewCell stress2021
The evolution of the concept of stress and the framework of the stress system.
Review in Cell stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07396675 (Improving Postoperative Debriefings), which is not on this map. Cited by 87 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Postoperative Debriefings: the Added Value of Operating Room Black Box Supported Debriefings and Their Effect on Healthcare Professionals Perceived Effectiveness and Psychological Safety.
Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 213 citations in OpenAlex.
- Maternal Prenatal Stress and the Offspring Gut Microbiome: A Cross-Species Systematic Review.Developmental psychobiology · 2025Pooled it
- Association between androgenetic alopecia and psychological well-being: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Efficacy of auriculotherapy for decreasing anxiety and stress among perioperative nursing workers: a mixed study.Revista latino-americana de enfermagem · 2024Trial
- Exploring the efficacy and safety of a novel standardized ashwagandha (Journal of psychopharmacology (Oxford, England) · 2023Trial
- Electrodermal Activity, Behavior, and Context in Autistic People with High Support Needs: A Retrospective Ecological Study.Healthcare (Basel, Switzerland) · 2026Article
- When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Identification and characterization of the HSP gene family in the Chinese giant salamander: Expression patterns under combined environmental stress.BMC genomics · 2026Article
- Cumulative adverse social determinants of health and the odds of self-reported rheumatoid arthritis: a national study.Clinical rheumatology · 2026Article
- Implications of stress for animal welfare and animal-based researchLaboratory animals · 2026Review
- The Role of Antioxidants in the Connection Between Microbiota, Neuroinflammation and Epilepsy.Biomedicines · 2026Review
- Epigenetic Basis of Stress-Induced Central Nervous System Disorders: Therapeutic Approaches.Biology · 2026Review
- The Effect of Environmental Vulnerability on Family Caregiver Health.Oncology nursing forum · 2026Article
- Nutritional timing and stress biology: intermittent fasting as a hormetic signal for adaptation.Frontiers in nutrition · 2026Review
- Physiological responses and gut microbiota dynamics in beef cattle following transport stress syndrome with melatonin or dexmedetomidine administration.Frontiers in veterinary science · 2026Article
- What we get wrong about stress in sports psychology: an opinion.Frontiers in psychology · 2026Article
- Article
- Gut microbiota dysbiosis is associated with hippocampal neuronal damage and behavioral alterations in APP/PS1 mice with high-salt diet.Frontiers in microbiology · 2026Article
- Allostatic load and uterine fibroids: role in pathogenesis and racial disparities.Uterine research · 2026Review
- Preliminary assessment of the leukocyte coping capacity as a point of care marker in horses with stress associated diseases.BMC veterinary research · 2025Article
- The negative responses and acclimation mechanisms of Neopyropia yezoensis conchocelis filaments to short- and long-term ocean acidification.BMC plant biology · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress is a central concept in biology and has now been widely used in psychological, physiological, social, and even environmental fields. However, the concept of stress was cross-utilized to refer to different elements of the stress system including stressful stimulus, stressor, stress response, and stress effect. Here, we summarized the evolution of the concept of stress and the framework of the stress system. We find although the concept of stress is developed from Selye's "general adaptation syndrome", it has now expanded and evolved significantly. Stress is now defined as a state of homeostasis being challenged, including both system stress and local stress. A specific stressor may potentially bring about specific local stress, while the intensity of stress beyond a threshold may commonly activate the hypothalamic-pituitary-adrenal axis and result in a systematic stress response. The framework of the stress system indicates that stress includes three types: sustress (inadequate stress), eustress (good stress), and distress (bad stress). Both sustress and distress might impair normal physiological functions and even lead to pathological conditions, while eustress might benefit health through hormesis-induced optimization of homeostasis. Therefore, an optimal stress level is essential for building biological shields to guarantee normal life processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.