ArticleNeurobiology of stress2021
Insights from a laboratory and naturalistic investigation on stress, rumination and frontal brain functioning in MDD: An fNIRS study.
Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Investigating the neural and behavioral correlates of the stress-rumination link in healthy humans by modulating the left Dorsolateral Prefrontal Cortex using Theta Burst Stimulation.Cognitive, affective & behavioral neuroscience · 2025Trial
- Temporal dynamics of CBT emotion regulation training in patients with major depression using ecological momentary assessment.Scientific reports · 2025Trial
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy.Frontiers in psychiatry · 2026Article
- Rumination Out Loud? Linguistic, Neural, and Psychophysiological Correlates of the Think-Aloud Paradigm.Depression and anxiety · 2026Article
- Extracranial Hemodynamic Responses to a Noxious Cold Pressor Task Differ Between Persistent Post-Traumatic Headache and Healthy Controls.Journal of personalized medicine · 2025Article
- Cognitive appraisal modulates Theta Burst Stimulation effects on stress-reactive rumination and affect.Cognitive, affective & behavioral neuroscience · 2025Article
- Repeated theta burst stimulation of the right ventrolateral prefrontal cortex reveals strong habituation in the context of stress and rumination.Scientific reports · 2025Article
- The temporal dynamics of perceived stress and depression in college students: An ecological momentary assessment.PsyCh journal · 2025Article
- Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation.Neurobiology of stress · 2025Article
- Contrasting Individual-Specific Resilience and Compensation Personalization Frameworks: The Case of Rumination.Biological psychiatry global open science · 2025Article
- Bidirectional Dynamics Between Stress-Reactive Rumination and Negative Affect: Evidence From a Multimethods Study in Individuals With High Trait Anxiety.Depression and anxiety · 2025Article
- Neural correlates of stress-reactive rumination in depression - The role of childhood trauma and social anxiety.Neurobiology of stress · 2024Article
- On assessing trait rumination using the Ruminative Response Scale.Frontiers in psychology · 2024Article
- Emotion regulation use in daily-life and its association with success of emotion-regulation, self-efficacy, stress, and state rumination.Frontiers in psychology · 2024Article
- Self-objectification and eating disorders: the psychopathological and neural processes from psychological distortion to psychosomatic illness.Psychoradiology · 2024Review
- Prefrontal hypoactivation induced via social stress is more strongly associated with state rumination than depressive symptomatology.Scientific reports · 2023Article
- Trait rumination and social anxiety separately influence stress-induced rumination and hemodynamic responses.Scientific reports · 2022Article
- Vortioxetine Modulates the Regional Signal in First-Episode Drug-Free Major Depressive Disorder at Rest.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent research has emphasized rumination as an important maintaining factor in various mental disorders. However, operationalization and therefore induction of rumination in experimental settings poses a major challenge in terms of ecological validity. As stress seems to play a key role in everyday situations eliciting rumination, we conducted two stress paradigms while assessing behavioral and neurophysiological measures. Aiming to replicate previous findings on induced rumination by means of the Trier Social Stress Test (TSST) and comparing them to physiological (pain) stress, a clinical sample of patients with Major Depressive Disorder (MDD; n = 22) and healthy controls (HC; n = 23) was recruited. Cortical blood oxygenation was assessed during the stress paradigms using functional near-infrared spectroscopy (fNIRS). Further, we used ecological momentary assessment (EMA) of stress, rumination and mood to be able to correlate ruminative responses during induced stress and everyday rumination. Our results showed that social stress but not physiological stress induced depressive rumination in MDD but not in HC. Further, rumination reactivity in response to social stress but not to physiological stress was significantly associated with rumination reactivity in everyday life as assessed with EMA. With respect to cortical oxygenation, MDD subjects showed hypoactivity in the Cognitive Control Network during the TSST, which mediated the differences between MDD and HC in post-stress rumination. Our findings emphasize the role of negative social triggers in depressive rumination and validate the TSST as an induction method for depressive rumination. The results inform future developments in psychotherapeutic treatment for depressive rumination.
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