ArticleBio-protocol2021
Single or Repeated Ablation of Mouse Olfactory Epithelium by Methimazole.
Article in Bio-protocol, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- Eosinophil cationic protein-driven type 2 inflammation impairs olfactory function in a murine model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- Therapeutic Effects ofLife (Basel, Switzerland) · 2026Article
- Olfactory Disruption Restructures Collective Behavior and Increases Cohesive Group Dynamics.Biology · 2026Article
- Quiescent horizontal basal stem cells act as a niche for olfactory neurogenesis in a mouse 3D organoid model.Cell reports methods · 2025Article
- Opposing expression pattern of opsin 3 and opsin 5 in the developing and adult nasal epithelium.Chemical senses · 2025Article
- Noninvasive Diagnostic Method to Objectively Measure Olfaction and Diagnose Smell Disorders by a Molecularly Targeted Fluorescence Imaging Agent.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Article
- Article
- Immune responses in the injured olfactory and gustatory systems: a role in olfactory receptor neuron and taste bud regeneration?Chemical senses · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Odor-detecting olfactory sensory neurons residing in the nasal olfactory epithelium (OE) are the only neurons in direct contact with the external environment. As a result, these neurons are subjected to chemical, physical, and infectious insults, which may be the underlying reason why neurogenesis occurs in the OE of adult mammals. This feature makes the OE a useful model for studying neurogenesis and neuronal differentiation, with the possibility for systemic as well as local administration of various compounds and infectious agents that may interfere with these cellular processes. Several different chemical compounds have been shown to cause toxic injury to the OE, which can be used for OE ablation. We, and others, have found that the systemic administration of the hyperthyroid drug, methimazole, reliably causes olfactotoxicity as a side effect. Here, we outline an OE lesioning protocol for single or repeated ablation by methimazole. A single methimazole administration can be used to study neuroepithelial regeneration and stem cell activation, while repeated ablation and regeneration of OE enable the study of tissue stem cell exhaustion and generation of tissue metaplasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.