Evidence map›Paper›PMID 34124055›Full record

ArticleFrontiers in cell and developmental biology2021

Iron Overload-Induced Ferroptosis Impairs Porcine Oocyte Maturation and Subsequent Embryonic Developmental Competence

Weiyi Hu, Yan Zhang, Dali Wang, Tingting Yang, Jiajia Qi, Yonghong Zhang, Hao Jiang, Jiabao Zhang, Boxing Sun, Shuang Liang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Weiyi HuDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Yan ZhangDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Dali WangDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Tingting YangDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Jiajia QiDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Yonghong ZhangDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Hao JiangDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Jiabao ZhangDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Boxing SunDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Shuang LiangDepartment of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.
Jilin University · CNChungbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence indicates that ferroptosis is an iron-dependent form of regulated cell death. This type of iron-dependent programmed cell death is different from traditional forms of regulated cell death, such as apoptosis and autophagy. However, the role of ferroptosis in porcine oocyte maturation and the associated mechanism remain unclear. In the present research, we investigated the effects of ferric ammonium citrate (FAC), a specific ferroptosis inducer, on porcine oocyte meiotic maturation and quality and subsequent embryonic developmental competence. FAC treatment caused obvious accumulation of intracellular ferrous ions in porcine oocytes. At the end of the

Indexed as

ferroptosisiron overloadmitochondrial functionoxidative stressporcine oocyte

Identifiers

PMID34124055
PMCPMC8194094
OpenAlexW3170263119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.