Evidence map›Paper›PMID 34124020›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Morphological and Rheological Guided Design for the Microencapsulation Process of

Concetta Di Natale, Elena Lagreca, Valeria Panzetta, Marianna Gallo, Francesca Passannanti, Michele Vitale, Sabato Fusco, Raffaele Vecchione, Roberto Nigro, Paolo Netti

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Concetta Di NataleIstituto Italiano di Tecnologia, IIT@CRIB, Largo Barsanti e Matteucci, Naples, Italy.
Elena LagrecaIstituto Italiano di Tecnologia, IIT@CRIB, Largo Barsanti e Matteucci, Naples, Italy.
Valeria PanzettaIstituto Italiano di Tecnologia, IIT@CRIB, Largo Barsanti e Matteucci, Naples, Italy.
Marianna GalloDepartment of Chemical, Materials and Production Engineering, University of Naples Federico II, Naples, Italy.
Francesca PassannantiInnovation & Technology Provider (ITP S.r.l.), Naples, Italy.
Michele VitaleDepartment of Chemical, Materials and Production Engineering, University of Naples Federico II, Naples, Italy.
Sabato FuscoCentro di Ricerca Interdipartimentale sui Biomateriali CRIB, University of Naples Federico II, Naples, Italy.
Raffaele VecchioneIstituto Italiano di Tecnologia, IIT@CRIB, Largo Barsanti e Matteucci, Naples, Italy.
Roberto NigroDepartment of Chemical, Materials and Production Engineering, University of Naples Federico II, Naples, Italy.
Paolo NettiIstituto Italiano di Tecnologia, IIT@CRIB, Largo Barsanti e Matteucci, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal microbiota is a real ecosystem composed of several bacterial species and a very huge amount of strains that through their metabolic activities play a crucial role in the development and performance of the immune system and other functions. Microbiota modulation by probiotics establishes a new era into the pharmaceutical and healthcare market. Probiotics play, in fact, an important role in helping and sustaining human health, but in order to produce benefits, their viability must be preserved throughout the production process up to consumption, and in addition, their bioactivity required to be safeguarded while passing through the gastrointestinal tract. In this frame, encouraging results come from encapsulation strategies that have proven to be very promising in protecting bacteria and their viability. However, specific effort has to be dedicated to the design optimization of the encapsulation process and, in particular, to the processing parameters that affect capsules microstructure. Herein, focusing on calcium alginate microspheres, after a preliminary selection of their processing conditions based on size distribution, we implemented a micro-rheological analysis, by using the multiple-particle tracking technique, to correlate the inner microstructure to the selected process conditions and to the viability of the

Indexed as

calcium alginate microspheredrug deliverymicroencapsulationmultiple-particle trackingprobiotics

Identifiers

PMID34124020
PMCPMC8193927

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.