ReviewFrontiers in bioengineering and biotechnology2021
Engineering Microbes to Bio-Upcycle Polyethylene Terephthalate.
Review in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Robust cellular transformations of PET deconstruction products by import of glycol esters.Science advances · 2026Article
- Beyond carbon capture: bioengineering cyanobacteria as solar-driven platforms for remediation of recalcitrant human-generated waste.Frontiers in plant science · 2026Review
- Engineered microbes to enable a circular economy for biodegradable plastics.Frontiers in microbiology · 2026Review
- Construction of microbial systems for polyethylene terephthalate degradation.Synthetic and systems biotechnology · 2025Review
- Efficient biodegradation and upcycling of polyethylene terephthalate mediated by cell-factories.Frontiers in microbiology · 2025Review
- Perspectives on the microorganisms with the potentials of PET-degradation.Frontiers in microbiology · 2025Review
- Cutting-edge developments in plastic biodegradation and upcycling via engineering approaches.Metabolic engineering communications · 2024Article
- New combined absorption/Environmental science and pollution research international · 2024Article
- Microbial Upcycling of Waste PET to Adipic Acid.ACS central science · 2023Article
- Biotechnological Plastic Degradation and Valorization Using Systems Metabolic Engineering.International journal of molecular sciences · 2023Review
- Coexistence of specialist and generalist species within mixed plastic derivative-utilizing microbial communities.Microbiome · 2023Article
- Engineering microbial division of labor for plastic upcycling.Nature communications · 2023Article
- Functional tailoring of a PET hydrolytic enzyme expressed in Pichia pastoris.Bioresources and bioprocessing · 2023Article
- Repurposing of waste PET by microbial biotransformation to functionalized materials for additive manufacturing.Journal of industrial microbiology & biotechnology · 2023Article
- Recent Advances in the Chemobiological Upcycling of Polyethylene Terephthalate (PET) into Value-Added Chemicals.Journal of microbiology and biotechnology · 2023Review
- Trends inComputational and structural biotechnology journal · 2023Review
- Bioprospecting for polyesterase activity relevant for PET degradation in marine Enterobacterales isolates.AIMS microbiology · 2023Article
- Development of a yeast whole-cell biocatalyst for MHET conversion into terephthalic acid and ethylene glycol.Microbial cell factories · 2022Article
- Microbial degradation and valorization of poly(ethylene terephthalate) (PET) monomers.World journal of microbiology & biotechnology · 2022Review
- Mechanism-Based Design of Efficient PET Hydrolases.ACS catalysis · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyethylene terephthalate (PET) is globally the largest produced aromatic polyester with an annual production exceeding 50 million metric tons. PET can be mechanically and chemically recycled; however, the extra costs in chemical recycling are not justified when converting PET back to the original polymer, which leads to less than 30% of PET produced annually to be recycled. Hence, waste PET massively contributes to plastic pollution and damaging the terrestrial and aquatic ecosystems. The global energy and environmental concerns with PET highlight a clear need for technologies in PET "upcycling," the creation of higher-value products from reclaimed PET. Several microbes that degrade PET and corresponding PET hydrolase enzymes have been successfully identified. The characterization and engineering of these enzymes to selectively depolymerize PET into original monomers such as terephthalic acid and ethylene glycol have been successful. Synthetic microbiology and metabolic engineering approaches enable the development of efficient microbial cell factories to convert PET-derived monomers into value-added products. In this mini-review, we present the recent progress of engineering microbes to produce higher-value chemical building blocks from waste PET using a wholly biological and a hybrid chemocatalytic-biological strategy. We also highlight the potent metabolic pathways to bio-upcycle PET into high-value biotransformed molecules. The new synthetic microbes will help establish the circular materials economy, alleviate the adverse energy and environmental impacts of PET, and provide market incentives for PET reclamation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.