ArticleFrontiers in pediatrics2021
Screening of Chorioamnionitis Using Volatile Organic Compound Detection in Exhaled Breath: A Pre-clinical Proof of Concept Study.
Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Maternal urinary metabolomic signatures preceding spontaneous preterm birth: A pilot study.Scientific reports · 2025Article
- Novel biomarkers of fetal and neonatal environmental exposure, effect and susceptibility.Pediatric research · 2025Review
- Article
- AntenatalInternational journal of molecular sciences · 2024Article
- Ureaplasma-Driven Neonatal Neuroinflammation: Novel Insights from an Ovine Model.Cellular and molecular neurobiology · 2023Article
- Insights into the Black Box of Intra-Amniotic Infection and Its Impact on the Premature Lung: From Clinical and Preclinical Perspectives.International journal of molecular sciences · 2022Review
- Detection of spontaneous preterm birth by maternal urinary volatile organic compound analysis: A prospective cohort study.Frontiers in pediatrics · 2022Article
- Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chorioamnionitis is a major risk factor for preterm birth and an independent risk factor for postnatal morbidity for which currently successful therapies are lacking. Emerging evidence indicates that the timing and duration of intra-amniotic infections are crucial determinants for the stage of developmental injury at birth. Insight into the dynamical changes of organ injury after the onset of chorioamnionitis revealed novel therapeutic windows of opportunity. Importantly, successful development and implementation of therapies in clinical care is currently impeded by a lack of diagnostic tools for early (prenatal) detection and surveillance of intra-amniotic infections. In the current study we questioned whether an intra-amniotic infection could be accurately diagnosed by a specific volatile organic compound (VOC) profile in exhaled breath of pregnant sheep. For this purpose pregnant Texel ewes were inoculated intra-amniotically with
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Registered trials
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