Evidence map›Paper›PMID 34123813›Full record

ArticleFrontiers in oncology2021

Using Liposomes to Alleviate the Toxicity of Chelerythrine, a Natural PKC Inhibitor, in Treating Non-Small Cell Lung Cancer.

Jiahui Wang, Yijie Song, Ning Zhang, Ning Li, Congying Liu, Bing Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jiahui WangExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yijie SongExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ning ZhangExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ning LiShenzhen Research Institute, The Hong Kong University of Science and Technology, Shenzhen, China.
Congying LiuExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Bing WangSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai University of Traditional Chinese Medicine · CNChinese Academy of Sciences · CNHong Kong University of Science and Technology · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyCHE can inhibit the proliferation of lung cancer cells and induce apoptosis. However, despite having

methodsThe antitumor effect of CHE on HCC827 was evaluated, and its potential work mechanism was investigated. CHE long circulation liposomes (CHELPs) modified with polyethylene glycol have been optimized and characterized by

resultsCHE might inhibit HCC827 growth through the ROS/PKC-

conclusionsCHE is a candidate drug for NSCLC, and liposomes are effective in alleviating the toxicity of CHE.

Indexed as

antitumor effectsapoptosischelerythrineliposomenon-small cell lung cancer

Identifiers

PMID34123813
PMCPMC8190388
OpenAlexW3170638207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.