ReviewJournal of addiction2021
Areca Nut Chewing: Initiation, Addiction, and Harmful Effects Emphasizing the Barriers and Importance of Cessation.
Review in Journal of addiction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Areca Nut and Oral Cancer: Evidence from Studies Conducted in Humans.Journal of dental research · 2022Pooled it
- Article
- The multistep progression of areca nut-induced oral cancer: a mechanistic roadmap from pathogenesis to precision therapy.Life medicine · 2026Review
- Article
- 3D Comparative Evaluation of Condylar Morphology Between Chronic Areca Nut Chewers and Nonchewers: Protocol for a Case-Control Study.JMIR research protocols · 2026Article
- Understanding betel nut addiction: a review of harmful consequences, underlying neurobiology, and emerging intervention strategies.Translational psychiatry · 2026Review
- Effectiveness ofInternational journal of clinical pediatric dentistry · 2026Article
- An organoid-guided roadmap for precision delivery of epigallocatechin gallate in oral submucous fibrosis.Frontiers in bioengineering and biotechnology · 2026Review
- Molecular mechanisms of therapeutic resistance in areca nut-associated oral squamous cell carcinoma: the interplay of chronic inflammation and epithelial-mesenchymal transition.Frontiers in oncology · 2026Review
- Clinical and Pathophysiological Significance of Trace Elements in Oral Potentially Malignant Disorders and Oral Cancer: A 20-Year Narrative Review for Evidence-Based Public Health Intervention.International journal of dentistry · 2026Review
- Periodontitis presenting among betel quid users: A case series.Clinical advances in periodontics · 2025Article
- Oxidative stress markers as a diagnostic tool in oral cancer and premalignant lesions: A systematic review.Journal of dental research, dental clinics, dental prospects · 2025Review
- Use of betel quid with and without tobacco and challenges to quitting among women attending a rural hospital in Sri Lanka.BMC oral health · 2025Article
- The Role of Genetics in Human Oral Health: A Systematic-Narrative Review.Dentistry journal · 2025Review
- Oral submucosal fibrosis: a comprehensive review on pathogenesis, diagnosis, therapeutics and computational advances.Frontiers in cell and developmental biology · 2025Review
- Modulation of neural activity and gene expression by arecoline.Frontiers in integrative neuroscience · 2025Article
- Perceived stress and betel quid dependence associated with reasons for betel quid chewing among male chewers: a mixed methods study.BMC oral health · 2024Article
- Mechanism of curcumin in the prevention and treatment of oral submucosal fibrosis and progress in clinical application research.BDJ open · 2024Review
- A scientometric study on research trends and characteristics of oral submucous fibrosis.Journal of dental sciences · 2024Article
- Brief psychotic disorder related to areca nut use: a case report.Frontiers in psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Areca nut is a highly addictive substance with carcinogenic properties and causes many harmful effects to the human body. Alkaloids are the major chemicals found in areca nut, and their mechanism of action has been studied for several years. About 600 million people around the world use areca nut, and its usage is higher in Asian countries. Areca nut chewers get used to the habit mainly due to social influence, stress, or lack of awareness. Some studies have reported a dependence syndrome related to areca nut chewing. Even though there are many ongoing research studies regarding tobacco addiction, less concern has been given to the areca nut addiction. There are only few studies related to areca nut cessation, and even those few cessation programs are mainly designed using tobacco cessation methodology. Sociocultural influence, behavioral factors, and accessibility are the main barriers to cessation. Behavior changing interventions proved to be more effective in areca nut cessation, but recently studies on pharmacological therapies are also emerging.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.