Evidence map›Paper›PMID 34123328›Full record

ArticleChemical science2021

Library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity.

Ru-Bing Wang, Shuang-Gang Ma, Cooper S Jamieson, Rong-Mei Gao, Yun-Bao Liu, Yong Li, Xiao-Jing Wang, Yu-Huan Li, Kendall N Houk, Jing Qu and 1 more

Abstract read
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In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The Diels-Alder Reaction as a Key Step in Natural Product Synthesis.Progress in the chemistry of organic natural products · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ru-Bing WangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College No.1 Xian Nong Tan Street Beijing 100050 People's Republic of China mashuanggang@imm.ac.cn qujing@imm.ac.cn yushishan@imm.ac.cn.
Shuang-Gang MaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College No.1 Xian Nong Tan Street Beijing 100050 People's Republic of China mashuanggang@imm.ac.cn qujing@imm.ac.cn yushishan@imm.ac.cn.ORCID https://orcid.org/0000-0002-1065-154X
Cooper S JamiesonDepartment of Chemistry and Biochemistry, University of California Los Angeles California 90095 USA houk@chem.ucla.edu.
Rong-Mei GaoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College No. 1 Tian Tan Xi Li Beijing 100050 People's Republic of China.
Yun-Bao LiuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College No.1 Xian Nong Tan Street Beijing 100050 People's Republic of China mashuanggang@imm.ac.cn qujing@imm.ac.cn yushishan@imm.ac.cn.
Yong LiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College No.1 Xian Nong Tan Street Beijing 100050 People's Republic of China mashuanggang@imm.ac.cn qujing@imm.ac.cn yushishan@imm.ac.cn.ORCID https://orcid.org/0000-0003-1672-6589
Xiao-Jing WangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College No.1 Xian Nong Tan Street Beijing 100050 People's Republic of China mashuanggang@imm.ac.cn qujing@imm.ac.cn yushishan@imm.ac.cn.
Yu-Huan LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College No. 1 Tian Tan Xi Li Beijing 100050 People's Republic of China.
Kendall N HoukDepartment of Chemistry and Biochemistry, University of California Los Angeles California 90095 USA houk@chem.ucla.edu.ORCID https://orcid.org/0000-0002-8387-5261
Jing QuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College No.1 Xian Nong Tan Street Beijing 100050 People's Republic of China mashuanggang@imm.ac.cn qujing@imm.ac.cn yushishan@imm.ac.cn.
Shi-Shan YuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College No.1 Xian Nong Tan Street Beijing 100050 People's Republic of China mashuanggang@imm.ac.cn qujing@imm.ac.cn yushishan@imm.ac.cn.ORCID https://orcid.org/0000-0002-0821-9029

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The construction of libraries of stereoisomers of natural products serves as an important approach to investigating the correlation between the stereostructure and biological activity. However, the total synthesis and isomerzation of polycyclic scaffolds with multiple chrial centers are rare. Spirooliganin (

Identifiers

PMID34123328
PMCPMC8153216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.