Evidence map›Paper›PMID 34123298›Full record

ArticleChemical science2020

A programmable chemical switch based on triggerable Michael acceptors.

Jiaming Zhuang, Bo Zhao, Xiangxi Meng, Jessica D Schiffman, Sarah L Perry, Richard W Vachet, S Thayumanavan

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 56 citations in OpenAlex.

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  14. Redox-Controlled Shunts in a Synthetic Chemical Reaction Cycle.Journal of the American Chemical Society · 2023
    Article
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  19. Article
  20. Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry.Journal of the American Chemical Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiaming ZhuangDepartment of Chemistry, University of Massachusetts Amherst Massachusetts 01003 USA jzhuang@chem.umass.edu thai@chem.umass.edu.ORCID https://orcid.org/0000-0001-5969-3946
Bo ZhaoDepartment of Chemistry, University of Massachusetts Amherst Massachusetts 01003 USA jzhuang@chem.umass.edu thai@chem.umass.edu.
Xiangxi MengDepartment of Chemical Engineering, University of Massachusetts Amherst Massachusetts 01003 USA.
Jessica D SchiffmanCenter for Bioactive Delivery, Institute for Applied Life Science, University of Massachusetts Amherst Massachusetts 01003 USA.ORCID https://orcid.org/0000-0002-1265-5392
Sarah L PerryCenter for Bioactive Delivery, Institute for Applied Life Science, University of Massachusetts Amherst Massachusetts 01003 USA.ORCID https://orcid.org/0000-0003-2301-6710
Richard W VachetDepartment of Chemistry, University of Massachusetts Amherst Massachusetts 01003 USA jzhuang@chem.umass.edu thai@chem.umass.edu.ORCID https://orcid.org/0000-0003-4514-0210
S ThayumanavanDepartment of Chemistry, University of Massachusetts Amherst Massachusetts 01003 USA jzhuang@chem.umass.edu thai@chem.umass.edu.ORCID https://orcid.org/0000-0002-6475-6726
Amherst College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing an engineerable chemical reaction that is triggerable for simultaneous chemical bond formation and cleavage by external cues offers tunability and orthogonality which is highly desired in many biological and materials applications. Here, we present a chemical switch that concurrently captures these features in response to chemically and biologically abundant and important cues,

Identifiers

PMID34123298
PMCPMC8150097
OpenAlexW2999708683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.