Evidence map›Paper›PMID 34123217›Full record

ArticleChemical science2020

Anodic oxidation triggered divergent 1,2- and 1,4-group transfer reactions of β-hydroxycarboxylic acids enabled by electrochemical regulation.

Zhenxing Zhang, Lei Zhang, Xianhao Zhang, Jianxin Yang, Yunxing Yin, Yangye Jiang, Chengchu Zeng, Gang Lu, Yang Yang, Fanyang Mo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhenxing ZhangDepartment of Energy and Resources Engineering, College of Engineering, Peking University Beijing 100871 China fmo@pku.edu.cn.
Lei ZhangDepartment of Energy and Resources Engineering, College of Engineering, Peking University Beijing 100871 China fmo@pku.edu.cn.
Xianhao ZhangWuXi AppTec (Tianjin) Co., Ltd Tianjin 300457 P. R. China.
Jianxin YangWuXi AppTec (Tianjin) Co., Ltd Tianjin 300457 P. R. China.
Yunxing YinWuXi AppTec (Tianjin) Co., Ltd Tianjin 300457 P. R. China.
Yangye JiangCollege of Life Science & Bioengineering, Beijing University of Technology Beijing 100124 China.
Chengchu ZengCollege of Life Science & Bioengineering, Beijing University of Technology Beijing 100124 China.ORCID https://orcid.org/0000-0002-5659-291X
Gang LuSchool of Chemistry and Chemical Engineering, Shandong University Jinan Shandong 250100 China.
Yang YangDepartment of Chemistry and Biochemistry, University of California Santa Barbara California 93106 USA.ORCID https://orcid.org/0000-0002-4956-2034
Fanyang MoDepartment of Energy and Resources Engineering, College of Engineering, Peking University Beijing 100871 China fmo@pku.edu.cn.ORCID https://orcid.org/0000-0002-4140-3020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a set of electrochemically regulated protocols for the divergent synthesis of ketones and β-keto esters from the same β-hydroxycarboxylic acid starting materials. Enabled by electrochemical control, the anodic oxidation of carboxylic acids proceeded in either a one-electron or a two-electron pathway, leading to a 1,4-aryl transfer or a semipinacol-type 1,2-group transfer product with excellent chemoselectivity. The 1,4-aryl transfer represents an unprecedented example of carbon-to-oxygen group transfer proceeding

Identifiers

PMID34123217
PMCPMC8162457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.