Evidence map›Paper›PMID 34123182›Full record

ArticleChemical science2020

Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment.

Shevanuja Theivendran, Jie Tang, Chang Lei, Yannan Yang, Hao Song, Zhengying Gu, Yue Wang, Yang Yang, Lei Jin, Chengzhong Yu

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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  9. Mitochondrial Proteins as Source of Cancer Neoantigens.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Shevanuja TheivendranAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland QLD 4072 Australia c.yu@uq.edu.au.
Jie TangAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland QLD 4072 Australia c.yu@uq.edu.au.
Chang LeiAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland QLD 4072 Australia c.yu@uq.edu.au.
Yannan YangAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland QLD 4072 Australia c.yu@uq.edu.au.
Hao SongAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland QLD 4072 Australia c.yu@uq.edu.au.ORCID https://orcid.org/0000-0002-6383-0605
Zhengying GuAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland QLD 4072 Australia c.yu@uq.edu.au.
Yue WangAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland QLD 4072 Australia c.yu@uq.edu.au.
Yang YangAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland QLD 4072 Australia c.yu@uq.edu.au.
Lei JinSchool of Medicine and Public Health, University of Newcastle NSW 2308 Australia.
Chengzhong YuAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland QLD 4072 Australia c.yu@uq.edu.au.ORCID https://orcid.org/0000-0003-3707-0785
The University of Queensland · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post translational modifications (PTM) such as phosphorylation are often correlated with tumorigenesis and malignancy in breast cancer. Herein, we report a PTM-assisted strategy as a simplified version of a personalized cancer vaccine for enhanced cancer immunotherapy. Titanium modified dendritic mesoporous silica nanoparticles (TiDMSN) are applied to assist the specific enrichment of phosphorylated tumor antigens released upon immunogenic cell death. This strategy significantly improved the tumor inhibition efficacy in a bilateral breast cancer model and the expansion of both CD8

Identifiers

PMID34123182
PMCPMC8162284
OpenAlexW3083990150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.