Evidence map›Paper›PMID 34123144›Full record

ArticleChemical science2020

Development of photo- and chemo-stable near-infrared-emitting dyes: linear-shape benzo-rosol and its derivatives as unique ratiometric bioimaging platforms.

Mingchong Dai, Ye Jin Reo, Chang Wook Song, Yun Jae Yang, Kyo Han Ahn

Abstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Hybrid of Indolizine and Merocyanine-A New Class of Organelle-Specific Dyes.Angewandte Chemie (International ed. in English) · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mingchong DaiDepartment of Chemistry, Pohang University of Science and Technology (POSTECH) 77 Cheongam-Ro, Nam-Gu Pohang Gyungbuk 37673 Republic of Korea ahn@postech.ac.kr.ORCID https://orcid.org/0000-0002-4708-637X
Ye Jin ReoDepartment of Chemistry, Pohang University of Science and Technology (POSTECH) 77 Cheongam-Ro, Nam-Gu Pohang Gyungbuk 37673 Republic of Korea ahn@postech.ac.kr.ORCID https://orcid.org/0000-0001-7445-8477
Chang Wook SongDepartment of Chemistry, Pohang University of Science and Technology (POSTECH) 77 Cheongam-Ro, Nam-Gu Pohang Gyungbuk 37673 Republic of Korea ahn@postech.ac.kr.
Yun Jae YangDepartment of Chemistry, Pohang University of Science and Technology (POSTECH) 77 Cheongam-Ro, Nam-Gu Pohang Gyungbuk 37673 Republic of Korea ahn@postech.ac.kr.
Kyo Han AhnDepartment of Chemistry, Pohang University of Science and Technology (POSTECH) 77 Cheongam-Ro, Nam-Gu Pohang Gyungbuk 37673 Republic of Korea ahn@postech.ac.kr.ORCID https://orcid.org/0000-0001-7192-7215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microscopic imaging aided with fluorescent probes has revolutionized our understanding of biological systems. Organic fluorophores and probes thus continue to evolve for bioimaging applications. Fluorophores such as cyanines and hemicyanines emit in the near-infrared (NIR) region and thus allow deeper imaging with minimal autofluorescence; however, they show limited photo- and chemo-stability, demanding new robust NIR fluorophores. Such photo- and chemo-stable NIR fluorophores, linear-shape π-extended rosol and rosamine analogues, are disclosed here which provide bright fluorescence images in cells as well as in tissues by confocal laser-scanning microscopy. Furthermore, they offer unique ratiometric imaging platforms for activatable probes with dual excitation and dual emission capability, as demonstrated with a 2,4-dinitrophenyl ether derivative of benzo-rosol.

Identifiers

PMID34123144
PMCPMC8163444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.