Evidence map›Paper›PMID 34123120›Full record

ArticleChemical science2020

Understanding the factors controlling the photo-oxidation of natural DNA by enantiomerically pure intercalating ruthenium polypyridyl complexes through TA/TRIR studies with polydeoxynucleotides and mixed sequence oligodeoxynucleotides.

Páraic M Keane, Kyra O'Sullivan, Fergus E Poynton, Bjørn C Poulsen, Igor V Sazanovich, Michael Towrie, Christine J Cardin, Xue-Zhong Sun, Michael W George, Thorfinnur Gunnlaugsson and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Páraic M KeaneSchool of Chemistry, Trinity College Dublin, The University of Dublin Dublin 2 Ireland pakeane@tcd.ie jmkelly@tcd.ie.ORCID https://orcid.org/0000-0003-2828-8512
Kyra O'SullivanSchool of Chemistry, Trinity College Dublin, The University of Dublin Dublin 2 Ireland pakeane@tcd.ie jmkelly@tcd.ie.
Fergus E PoyntonSchool of Chemistry, Trinity College Dublin, The University of Dublin Dublin 2 Ireland pakeane@tcd.ie jmkelly@tcd.ie.
Bjørn C PoulsenSchool of Chemistry, Trinity College Dublin, The University of Dublin Dublin 2 Ireland pakeane@tcd.ie jmkelly@tcd.ie.
Igor V SazanovichCentral Laser Facility, Research Complex at Harwell, Science and Technology Facilities Council, Rutherford Appleton Laboratories OX11 0QX UK.
Michael TowrieCentral Laser Facility, Research Complex at Harwell, Science and Technology Facilities Council, Rutherford Appleton Laboratories OX11 0QX UK.
Christine J CardinSchool of Chemistry, University of Reading RG6 6AD UK.
Xue-Zhong SunSchool of Chemistry, University of Nottingham NG7 2RD UK.
Michael W GeorgeSchool of Chemistry, University of Nottingham NG7 2RD UK.ORCID https://orcid.org/0000-0002-7844-1696
Thorfinnur GunnlaugssonSchool of Chemistry, Trinity College Dublin, The University of Dublin Dublin 2 Ireland pakeane@tcd.ie jmkelly@tcd.ie.ORCID https://orcid.org/0000-0003-4814-6853
Susan J QuinnSchool of Chemistry, University College Dublin Dublin 4 Ireland susan.quinn@ucd.ie.ORCID https://orcid.org/0000-0002-7773-8842
John M KellySchool of Chemistry, Trinity College Dublin, The University of Dublin Dublin 2 Ireland pakeane@tcd.ie jmkelly@tcd.ie.ORCID https://orcid.org/0000-0002-3706-1777
University College Dublin · IERutherford Appleton Laboratory · GBUniversity of Nottingham · GBUniversity of Nottingham Ningbo China · CNUniversity of Reading · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ruthenium polypyridyl complexes which can sensitise the photo-oxidation of nucleic acids and other biological molecules show potential for photo-therapeutic applications. In this article a combination of transient visible absorption (TrA) and time-resolved infra-red (TRIR) spectroscopy are used to compare the photo-oxidation of guanine by the enantiomers of [Ru(TAP)

Identifiers

PMID34123120
PMCPMC8163394
OpenAlexW3047623828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.