Evidence map›Paper›PMID 34123038›Full record

ArticleChemical science2019

A side-chain engineering strategy for constructing fluorescent dyes with direct and ultrafast self-delivery to living cells.

Lifang Guo, Chuanya Li, Hai Shang, Ruoyao Zhang, Xuechen Li, Qing Lu, Xiao Cheng, Zhiqiang Liu, Jing Zhi Sun, Xiaoqiang Yu

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 47 citations in OpenAlex.

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  2. Biolipid Film-Fused Electrochemiluminescence for Multipurpose In Situ Bioassays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  4. Alkyl chain length-regulatedAsian journal of pharmaceutical sciences · 2024
    Article
  5. Styrylpyridinium Derivatives for Fluorescent Cell Imaging.Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Lifang GuoCenter of Bio & Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University Jinan 250100 P. R. China yuxq@sdu.edu.cn zqliu@sdu.edu.cn.
Chuanya LiCenter of Bio & Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University Jinan 250100 P. R. China yuxq@sdu.edu.cn zqliu@sdu.edu.cn.
Hai ShangInstitute of Robotics, Shanghai Jiao Tong University Shanghai 200240 P. R. China.
Ruoyao ZhangCenter of Bio & Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University Jinan 250100 P. R. China yuxq@sdu.edu.cn zqliu@sdu.edu.cn.
Xuechen LiCenter of Bio & Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University Jinan 250100 P. R. China yuxq@sdu.edu.cn zqliu@sdu.edu.cn.
Qing LuCenter of Bio & Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University Jinan 250100 P. R. China yuxq@sdu.edu.cn zqliu@sdu.edu.cn.
Xiao ChengMoE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University Hangzhou 310027 P. R. China sunjz@zju.edu.cn.
Zhiqiang LiuCenter of Bio & Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University Jinan 250100 P. R. China yuxq@sdu.edu.cn zqliu@sdu.edu.cn.ORCID https://orcid.org/0000-0001-7863-1759
Jing Zhi SunMoE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University Hangzhou 310027 P. R. China sunjz@zju.edu.cn.ORCID https://orcid.org/0000-0001-5478-5841
Xiaoqiang YuCenter of Bio & Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University Jinan 250100 P. R. China yuxq@sdu.edu.cn zqliu@sdu.edu.cn.ORCID https://orcid.org/0000-0002-4313-6464
Shandong University · CNHangzhou Xixi hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organic fluorescent dyes with excellent self-delivery to living cells are always difficult to find due to the limitation of the plasma membrane having rigorous selectivity. Herein, in order to improve the permeability of dyes, we utilize a side-chain engineering strategy (SCES): adjusting the side-chain length of dyes to fine-tune the adsorption and desorption processes on the membrane-aqueous phase interfaces of the outer and inner leaflets of the plasma membrane. For this, a family of fluorescent derivatives (

Identifiers

PMID34123038
PMCPMC8145637
OpenAlexW2992749720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.