ArticleChemical science2020
Core remodeling leads to long wavelength fluoro-coumarins.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- A modular artificial intelligence framework to facilitate fluorophore design.Nature communications · 2025Article
- Ratio-based indicators for cytosolic CaProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Expedient Synthesis and Characterization of π-Extended Luciferins.The Journal of organic chemistry · 2024Article
- Design, Synthesis, and Evaluation of Small Fluorescent Molecules with a 1,1-Dimethylnaphthalen-2-(1Molecules (Basel, Switzerland) · 2024Article
- Ultra-photostable small-molecule dyes facilitate near-infrared biophotonics.Nature communications · 2024Article
- Azaphosphinate Dyes: A Low Molecular Weight Near-Infrared Scaffold for Development of Photoacoustic or Fluorescence Imaging Probes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Exploring Structural-Photophysical Property Relationships in Mitochondria-Targeted Deep-Red/NIR-Emitting Coumarins.International journal of molecular sciences · 2023Article
- Computational Design of Molecular Probes for Electronic Preresonance Raman Scattering Microscopy.The journal of physical chemistry. B · 2023Article
- Engineering fluorescent protein chromophores with an internal reference for high-fidelity ratiometric G4 imaging in living cells.Chemical science · 2023Article
- Miniaturized Chemical Tags for Optical Imaging.Angewandte Chemie (International ed. in English) · 2022Review
- Article
- Green-Light Activatable BODIPY and Coumarin 5'-Caps for Oligonucleotide Photocaging.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Fluorogenic Cyclopropenones for Multicomponent, Real-Time Imaging.Journal of the American Chemical Society · 2022Article
- Ketone Incorporation Extends the Emission Properties of the Xanthene Scaffold Beyond 1000 nm.Photochemistry and photobiology · 2022Article
- Heteroatom-Substituted Xanthene Fluorophores Enter the Shortwave-Infrared Region.Photochemistry and photobiology · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Design, Synthesis, and Evaluation of Near-Infrared Fluorescent Molecules Based on 4H-1-Benzopyran Core.Molecules (Basel, Switzerland) · 2021Article
- Coumarins to Cyanines: Synthesis of Hemicyanines.Organic letters · 2021Article
- Coumarin luciferins and mutant luciferases for robust multi-component bioluminescence imaging.Chemical science · 2021Article
- FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices.eLife · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low molecular weight, uncharged far-red and NIR dyes would be enabling for a range of imaging applications. Rational redesign of the coumarin scaffold leads to Fluoro-Coumarins (FCs), the lowest molecular weight dyes with emission maxima beyond 700, 800, and 900 nm. FCs display large Stokes shifts and high environmental sensitivity, with a 40-fold increase in emission intensity in hydrophobic solvents. Untargeted variants exhibit selective lipid droplet and nuclear staining in live cells. Furthermore, sulfo-lipid derivatization enables active targeting to the plasma membrane. Overall, these studies report a promising platform for the development of biocompatible, context-responsive imaging agents.
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Registered trials
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