Evidence map›Paper›PMID 34122978›Full record

ArticleChemical science2020

Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics.

Luoyi Wang, Zhongshu Song, Paul R Race, James Spencer, Thomas J Simpson, Matthew P Crump, Christine L Willis

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Mutasynthesis and Antibiotic Activity of Mupirocin Analogues.Chembiochem : a European journal of chemical biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Luoyi WangSchool of Chemistry, University of Bristol Cantock's Close BS8 1TS Bristol UK chris.willis@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0003-2032-7206
Zhongshu SongSchool of Chemistry, University of Bristol Cantock's Close BS8 1TS Bristol UK chris.willis@bristol.ac.uk matt.crump@bristol.ac.uk.
Paul R RaceSchool of Biochemistry, University of Bristol University Walk BS8 1TD Bristol UK.ORCID https://orcid.org/0000-0003-0184-5630
James SpencerSchool of Cellular and Molecular Medicine, University of Bristol BS8 1TD Bristol UK.ORCID https://orcid.org/0000-0002-4602-0571
Thomas J SimpsonSchool of Chemistry, University of Bristol Cantock's Close BS8 1TS Bristol UK chris.willis@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0003-0777-1935
Matthew P CrumpSchool of Chemistry, University of Bristol Cantock's Close BS8 1TS Bristol UK chris.willis@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0002-7868-5818
Christine L WillisSchool of Chemistry, University of Bristol Cantock's Close BS8 1TS Bristol UK chris.willis@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0002-3919-3642
University of Bristol · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L01386X/1
6 · The paper itself

Abstract

With growing understanding of the underlying pathways of polyketide biosynthesis, along with the continual expansion of the synthetic biology toolkit, it is becoming possible to rationally engineer and fine-tune the polyketide biosynthetic machinery for production of new compounds with improved properties such as stability and/or bioactivity. However, engineering the pathway to the thiomarinol antibiotics has proved challenging. Here we report that genes from a marine

Identifiers

PMID34122978
PMCPMC8159325
OpenAlexW3022893574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.