ReviewChemical science2020
Enlightening advances in polymer bioconjugate chemistry: light-based techniques for grafting to and from biomacromolecules.
Review in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Oxygen-Tolerant Photo-Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA-ATRP) for High-Throughput Synthesis of Polymer Bioconjugates.Angewandte Chemie (International ed. in English) · 2026Article
- Photo-Organocatalyzed Synthesis of Hard-Soft-Hard Triblock Copolymers From Tetrafluoroethylene: Facile Access to Hydrogen-Bonded Thermoplastic Fluoroelastomers.Angewandte Chemie (International ed. in English) · 2026Article
- Halogen Effect in Dual-Catalysis PhotoATRP.Macromolecules · 2026Article
- Standardizing Depolymerization: Strategies and Performance Metrics.Precision chemistry · 2025Review
- Leveraging reactivity to gain precise control over macromolecular structures with photocatalysis in reversible-deactivation radical polymerizations.Chemical science · 2025Review
- Development of Smart Surfaces for Medicine and Biotechnology: Advances in Glass Functionalization through RDRP Techniques.ACS biomaterials science & engineering · 2025Review
- Artificial Zymogen Based on Protein-Polymer Hybrids.Biomacromolecules · 2024Article
- Aqueous photo-RAFT polymerization under ambient conditions: synthesis of protein-polymer hybrids in open air.Chemical science · 2024Article
- Red-Light-Driven Atom Transfer Radical Polymerization for High-Throughput Polymer Synthesis in Open Air.Journal of the American Chemical Society · 2023Article
- Conserved Protein-Polymer Interactions across Structurally Diverse Polymers Underlie Alterations to Protein Thermal Unfolding.ACS central science · 2023Article
- Fully Oxygen-Tolerant Visible-Light-Induced ATRP of Acrylates in Water: Toward Synthesis of Protein-Polymer Hybrids.Macromolecules · 2023Article
- Antibody-Biopolymer Conjugates in Oncology: A Review.Molecules (Basel, Switzerland) · 2023Review
- Photocrosslinkable natural polymers in tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Chemical Approaches to Synthetic Drug Delivery Systems for Systemic Applications.Angewandte Chemie (International ed. in English) · 2022Review
- Polynorbornene-based bioconjugates by aqueous grafting-from ring-opening metathesis polymerization reduce protein immunogenicity.Cell reports. Physical science · 2022Article
- Open-air green-light-driven ATRP enabled by dual photoredox/copper catalysis.Chemical science · 2022Article
- Expanding the functionality of proteins with genetically encoded dibenzo[Chemical science · 2022Article
- Molecular Self-Assembly and Supramolecular Chemistry of Cyclic Peptides.Chemical reviews · 2021Review
- Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly.Polymers · 2021Review
- Light-Triggered Click Chemistry.Chemical reviews · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Photochemistry has revolutionized the field of polymer-biomacromolecule conjugation. Ligation reactions necessitate biologically benign conditions, and photons have a significant energy advantage over what is available thermally at ambient temperature, allowing for rapid and unique reactivity. Photochemical reactions also afford many degrees of control, specifically, spatio-temporal control, light source tunability, and increased oxygen tolerance. Light-initiated polymerizations, in particular photo-atom-transfer radical polymerization (photo-ATRP) and photoinduced electron/energy transfer reversible addition-fragmentation chain transfer polymerization (PET-RAFT), have been used for grafting from proteins, DNA, and cells. Additionally, the spatio-temporal control inherent to light-mediated chemistry has been utilized for grafting biomolecules to hydrogel networks for many applications, such as 3-D cell culture. While photopolymerization has clear advantages, there are factors that require careful consideration in order to obtain optimal control. These factors include the photocatalyst system, light intensity, and wavelength. This Perspective aims to discuss recent advances of photochemistry for polymer biomacromolecule conjugation and potential considerations while tailoring these systems.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.