ArticleChemical science2020
Enantioselective aerobic oxidative cross-dehydrogenative coupling of glycine derivatives with ketones and aldehydes
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 95 citations in OpenAlex.
- Continuous-Flow Asymmetric Photocatalysis for the Synthesis of Natural and Unnatural α‑Amino Acid Derivatives.ACS organic & inorganic Au · 2026Article
- Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides.Journal of peptide science : an official publication of the European Peptide Society · 2026Review
- Radical cascade cyclization of amino acid-tethered 1,6-enynones with sulfonyl hydrazides for N-terminal modification: synthesis of functionalized succinimide derivatives.RSC advances · 2025Article
- Stabilized Carbon-Centered Radical-Mediated Carbosulfenylation of Styrenes: Modular Synthesis of Sulfur-Containing Glycine and Peptide Derivatives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Method for Rigorously Selective Capture and Simultaneous Fluorescent Labeling of N-Terminal Glycine Peptides.Journal of the American Chemical Society · 2024Article
- Dual-Comb Gas Sensor Integrated with a Neural Network-Based Spectral Decoupling Algorithm of Overlapped Spectra for Gas Mixture Sensing.ACS omega · 2023Article
- Triflamides and Triflimides: Synthesis and Applications.Molecules (Basel, Switzerland) · 2022Review
- Photoredox-Catalyzed C-H Functionalization Reactions.Chemical reviews · 2022Review
- Asymmetric Photocatalysis Enabled by Chiral Organocatalysts.ChemCatChem · 2022Article
- Radical-Based Synthesis and Modification of Amino Acids.Angewandte Chemie (International ed. in English) · 2021Review
- Recent developments in enantioselective photocatalysis.Beilstein journal of organic chemistry · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective aerobic oxidative cross-dehydrogenative coupling between glycine derivatives and simple ketones or aldehydes, which provides an efficient approach for the rapid synthesis of enantiopure unnatural α-alkyl α-amino acid derivatives in good yield with excellent diastereo- (up to >99 : 1) and enantioselectivities (up to 97% ee). This process includes the direct photoinduced oxidation of glycine derivatives to an imine intermediate, followed by the asymmetric Mannich-type reaction with an enamine intermediate generated
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Registered trials
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