ArticleChemical science2020
Steric and stereoscopic disulfide construction for cross-linkage
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A Programmable Cut-and-Sew Strategy for Trisulfide Transfer in the Synthesis of Cyclic Architectures.Journal of the American Chemical Society · 2026Article
- Thiol-Free Sulfenylation Redefined: A Single-Atom Transfer Pathway to Symmetrical Di(hetero)arylthioethers via B(CJournal of the American Chemical Society · 2026Article
- Preparation of Unsymmetrical Disulfides via Catalytic Lewis Base Activation ofThe Journal of organic chemistry · 2026Article
- A Dual-Mechanism Targeted Cross-Convergence Prodrug Activation Strategy Enabled by Biological Stimulus Amplification toward Precision Cancer Therapy.Biomaterials research · 2026Article
- Targeting Folate Receptors for the Detection and Selective Treatment of Cancer: Advanced Precision Oncology in Practice.International journal of biological sciences · 2026Review
- Photocatalytic Bilateral Disulfuration of Thioethers Toward α-Sulfide Disulfides With Antibacterial Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A facile, catalyst- and additive-free, and scalable approach to the photochemical preparation of disulfides from organosulfenyl chlorides.RSC advances · 2024Article
- Versatile Click Linker Enabling Native Peptide Release from Nanocarriers upon Redox Trigger.Bioconjugate chemistry · 2023Article
- Radical approaches to C-S bonds.Nature reviews. Chemistry · 2023Review
- Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols.Nature communications · 2022Article
- Decatungstate-catalyzed radical disulfuration through direct C-H functionalization for the preparation of unsymmetrical disulfides.Nature communications · 2022Article
- Selective synthesis of α-organylthio esters and α-organylthio ketones from β-keto esters and sodiumBeilstein journal of organic chemistry · 2021Article
- Trisulfide bond-mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity.Science advances · 2020Article
- Unsymmetrical polysulfidation via designed bilateral disulfurating reagents.Nature communications · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disulfide bonds are a significant motif in life and drug-delivery systems. In particular, steric hindrance and stereoscopic disulfide linkers are closely associated with the stability of antibody-drug conjugates, which affects the potency, selectivity, and pharmacokinetics of drugs. However, limited availability and diversity of tertiary thiols impede the construction of steric and stereoscopic disulfides for cross-linkage in biochemistry and pharmaceuticals. Through modulating the mask effect of disulfurating reagents, we develop a facile and robust strategy for construction of diverse steric and stereoscopic disulfides
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Registered trials
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