ArticleChemical science2020
Regiodivergent construction of medium-sized heterocycles from vinylethylene carbonates and allylidenemalononitriles.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity.Frontiers in oncology · 2022Article
- Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It.International journal of molecular sciences · 2021Review
- Triarylmethanes and their Medium-Ring Analogues by Unactivated Truce-Smiles Rearrangement of Benzanilides.Angewandte Chemie (International ed. in English) · 2021Article
- Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review.Chinese medicine · 2021Review
- A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles.Beilstein journal of organic chemistry · 2021Review
- Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds.Chemical science · 2020Article
- Synthesis of polysubstituted arenes through organocatalytic benzannulation.RSC advances · 2020Review
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Authors and funding
9 authors.
Funding
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Abstract
Medium-sized heterocycles exist in a broad spectrum of biologically active natural products and medicinally important synthetic compounds. The construction of medium-sized rings remains challenging, particularly the assembly of different ring sizes from the same type of substrate. Here we report palladium-catalyzed, regiodivergent [5 + 4] and [5 + 2] annulations of vinylethylene carbonates and allylidenemalononitriles. We describe the production of over 50 examples of nine- and seven-membered heterocycles in high isolated yields and excellent regioselectivities. We demonstrate the synthetic utility of this approach by converting a nine-membered ring product to an interesting polycyclic caged molecule
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Registered trials
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