Evidence map›Paper›PMID 34122720›Full record

ArticleOxidative medicine and cellular longevity2021

MicroRNA-145-Mediated KDM6A Downregulation Enhances Neural Repair after Spinal Cord Injury

Changzhao Gao, Fei Yin, Ran Li, Qing Ruan, Chunyang Meng, Kunchi Zhao, Qingsan Zhu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Deletion of the X-chromosomal geneScience translational medicine · 2025
    Article
  3. miR-539-5p Regulates Irritable Bowel Syndrome Pathological Processes by Targeting KDM6A.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Article
  4. Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Hallmarks of Brain Plasticity.Biomedicines · 2025
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Changzhao GaoDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Fei YinDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Ran LiDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Qing RuanDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Chunyang MengDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Kunchi ZhaoDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.ORCID https://orcid.org/0000-0002-7624-9262
Qingsan ZhuDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.ORCID https://orcid.org/0000-0002-9403-832X
Union Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) causes a significant physical, emotional, social, and economic burden to millions of people. MicroRNAs are known players in the regulatory circuitry of the neural repair in SCI. However, most microRNAs remain uncharacterized. Here, we demonstrate the neuroprotection of microRNA-145 (miR-145) after SCI

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily BDisease Models, AnimalDown-RegulationHistone DemethylasesMaleMicroRNAsRatsReceptor, Notch2Spinal Cord InjuriesATP Binding Cassette Transporter, Subfamily BHistone DemethylasesKdm6a protein, ratMicroRNAsMIRN145 microRNA, ratmultidrug resistance protein 3Notch2 protein, ratReceptor, Notch2

Identifiers

PMID34122720
PMCPMC8169274
OpenAlexW3165346586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.