Evidence map›Paper›PMID 34122455›Full record

ArticleFrontiers in immunology2021

Dectin-1-Mediated Production of Pro-Inflammatory Cytokines Induced by Yeast β-Glucans in Bovine Monocytes.

Ana R V Pedro, Tânia Lima, Ricardo Fróis-Martins, Bárbara Leal, Isabel C Ramos, Elisabete G Martins, Ana R J Cabrita, António J M Fonseca, Margarida R G Maia, Manuel Vilanova and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Anti-Inflammatory Effects ofInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. An immunoregulator nanomedicine approach for the treatment of tuberculosis.Frontiers in bioengineering and biotechnology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Ana R V PedroImmunobiology Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Tânia LimaImmunobiology Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Ricardo Fróis-MartinsImmunobiology Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Bárbara LealLaboratório de Imunogenética, DPIM, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Isabel C RamosAnimal Nutrition Division, Cooperativa Agrícola de Vila do Conde, Vila do Conde, Portugal.
Elisabete G MartinsADM Portugal, SA, Murtede, Portugal.
Ana R J CabritaLAQV, REQUIMTE, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
António J M FonsecaLAQV, REQUIMTE, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Margarida R G MaiaLAQV, REQUIMTE, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Manuel VilanovaImmunobiology Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Alexandra CorreiaImmunobiology Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Universidade do Porto · PTi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTRede de Química e Tecnologia · PTEscola Universitária Vasco da Gama · PTNanium (Portugal) · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yeast-derived products containing β-glucans have long been used as feed supplements in domesticated animals in an attempt to increase immunity. β-glucans are mainly recognized by the cell surface receptor CLEC7A, also designated Dectin-1. Although the immune mechanisms elicited through Dectin-1 activation have been studied in detail in mice and humans, they are poorly understood in other species. Here, we evaluated the response of bovine monocytes to soluble and particulate purified β-glucans, and also to Zymosan. Our results show that particulate, but not soluble β-glucans, can upregulate the surface expression of costimulatory molecules CD80 and CD86 on bovine monocytes. In addition, stimulated cells increased production of IL-8 and of

Indexed as

Animalsbeta-GlucansCattleCells, CulturedCytokinesDectin-1Inflammation MediatorsLectins, C-TypeLipopolysaccharide ReceptorsMonocytesSaccharomyces cerevisiaeUp-Regulationbeta-1,3-glucanbeta-GlucansCLEC7A protein, humanCytokinesDectin-1Inflammation MediatorsLectins, C-TypeLipopolysaccharide ReceptorsbovineCLEC7Acytokinesdectin-1monocytessiRNAβ-glucans

Identifiers

PMID34122455
PMCPMC8195389
OpenAlexW3170403653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.