Evidence map›Paper›PMID 34122453›Full record

ReviewFrontiers in immunology2021

Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure.

Jingyi Ding, Yanxi Liu, Yu Lai

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Searching for a HIV-1 Cure.Theranostics · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jingyi DingHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yanxi LiuUniversity of California, Los Angeles, Los Angeles, CA, United States.
Yu LaiSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the ability of combination antiretroviral therapy (cART) to increase the life expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs persist during life-long treatment. Notably, two cases of functional cure for HIV have been reported and are known as the "Berlin Patient" and the "London Patient". Both patients received allogeneic hematopoietic stem cell transplantation from donors with homozygous

Indexed as

Genetic TherapyHematopoietic Stem Cell TransplantationAnimalsAnti-HIV AgentsDonor SelectionGermanyHIVHIV InfectionsHodgkin DiseaseHomozygoteHost-Pathogen InteractionsHumansLeukemia, Myeloid, AcuteLiving DonorsLondonMutationAnti-HIV AgentsCCR5 protein, humanReceptors, CCR5combination antiretroviral therapycoreceptor-based hematopoietic stem cell gene therapyfunctional HIV curemilder conditioning regimensshock and kill strategies

Identifiers

PMID34122453
PMCPMC8190402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.