Evidence map›Paper›PMID 34122436›Full record

ArticleFrontiers in immunology2021

MelLec Exacerbates the Pathogenesis of

Kazuya Tone, Mark H T Stappers, Remi Hatinguais, Ivy M Dambuza, Fabián Salazar, Carol Wallace, Raif Yuecel, Petruta L Morvay, Kazuyoshi Kuwano, Janet A Willment and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  2. The C-type lectin receptor Dcir (Frontiers in immunology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kazuya ToneAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Mark H T StappersAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Remi HatinguaisAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Ivy M DambuzaAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Fabián SalazarAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Carol WallaceAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Raif YuecelIain Fraser Cytometry Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Petruta L MorvayAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Kazuyoshi KuwanoDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Janet A WillmentAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Gordon D BrownAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Medical Research Council · GBUniversity of Aberdeen · GBJikei University School of Medicine · JPUniversity of Exeter · GB

Funding

Medical Research Council MR/N006364/2Medical Research Council MR/V033417/1Wellcome Trust 097377Wellcome Trust 102705Wellcome Trust 102705/Z/13/Z
6 · The paper itself

Abstract

Environmental factors, particularly fungi, influence the pathogenesis of allergic airway inflammation, but the mechanisms underlying these effects are still unclear. Melanin is one fungal component which is thought to modulate pulmonary inflammation. We recently identified a novel C-type lectin receptor, MelLec (Clec1a), which recognizes fungal 1,8-dihydroxynaphthalene (DHN)-melanin and is able to regulate inflammatory responses. Here we show that MelLec promotes pulmonary allergic inflammation and drives the development of Th17 T-cells in response to spores of

Indexed as

AnimalsAspergillus fumigatusAsthmaBronchiCytokinesLectins, C-TypeMelaninsMiceMice, Inbred C57BLTh17 CellsCytokinesLectins, C-TypeMelaninsallergyAspergillus fumigatusasthmaC-type lectinMelLec

Identifiers

PMID34122436
PMCPMC8194280
OpenAlexW3167672060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.