Evidence map›Paper›PMID 34122431›Full record

ArticleFrontiers in immunology2021

Loss of CD96 Expression as a Marker of HIV-Specific CD8

Rémi Bunet, Manon Nayrac, Hardik Ramani, Mohamed Sylla, Madeleine Durand, Carl Chartrand-Lefebvre, Jean-Pierre Routy, Alan L Landay, Jean-Francois Gauchat, Nicolas Chomont and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. HIV-1 manipulates CD96 on CD4Science advances · 2025
    Article
  4. CX3CR1Inflammation and regeneration · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Enhancement of Human Immunodeficiency Virus-Specific CD8Pathogens (Basel, Switzerland) · 2024
    Article
  9. Review
  10. Review
  11. CD8International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Rémi BunetCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Manon NayracCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Hardik RamaniCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Mohamed SyllaCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Madeleine DurandCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Carl Chartrand-LefebvreCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Jean-Pierre RoutyResearch Institute of McGill University Health Centre, Montréal, QC, Canada.
Alan L LandayDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, United States.
Jean-Francois GauchatFaculté de Médecine, Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, QC, Canada.
Nicolas ChomontCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Petronela AncutaCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Daniel E KaufmannCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Nicole BernardResearch Institute of McGill University Health Centre, Montréal, QC, Canada.
Cécile L TremblayCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Mohamed El-FarCHUM-Research Centre, Montréal, Montréal, QC, Canada.
Centre Hospitalier de l’Université de Montréal · CAUniversité de Montréal · CAMcGill University Health Centre · CARush University Medical Center · US

Funding

Role of IL-32 as a predictor and mediator of Premature Aging Phenotypes(PAP) in HIV infection.R01AG054324 · NIA · CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (UNIVERSITY OF MONTREAL HOSPITAL) · PI TREMBLAY, CECILE · 2016 to 2025
$4.2M
CIHR HAL 398643CIHR PJT 148482CIHR PJT 168901NIA NIH HHS R01 AG054324
6 · The paper itself

Abstract

Persistent immune activation and inflammation in people living with HIV (PLWH) are associated with immunosenescence, premature aging and increased risk of non-AIDS comorbidities, with the underlying mechanisms not fully understood. In this study, we show that downregulation of the T-cell immunoglobulin receptor CD96 on CD8

Indexed as

AdultAntigens, CDCD8-Positive T-LymphocytesCell DifferentiationFemaleHIV InfectionsHumansLymphocyte ActivationMaleMiddle AgedAntigens, CDCD96 antigenCD96HIVpeople living with HIV (PLWH)T-cell dysfunction, IL-32T-cell senescence

Identifiers

PMID34122431
PMCPMC8190400
OpenAlexW3165891056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.