Evidence map›Paper›PMID 34122430›Full record

ArticleFrontiers in immunology2021

Integrated Analysis of Omics Data Reveal AP-1 as a Potential Regulation Hub in the Inflammation-Induced Hyperalgesia Rat Model.

Xiang Zhu, Feng Li, Miqun Wang, Huibin Su, Xuedong Wu, Haiyan Qiu, Wang Zhou, Chunli Shan, Cancan Wang, Lei Wei

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Xiang ZhuDepartment of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, China.
Feng LiThe Yancheng Clinical College of XuZhou Medical University, The First People's Hospital of Yancheng, Yancheng, China.
Miqun WangDepartment of Anesthesiology, Qingdao Women and Children's Hospital, Qingdao, China.
Huibin SuDepartment of Anesthesiology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
Xuedong WuDepartment of Anesthesiology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
Haiyan QiuDepartment of Anesthesiology, The First People's Hospital of Yancheng, Yancheng, China.
Wang ZhouDepartment of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, China.
Chunli ShanDepartment of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, China.
Cancan WangGraduate School of Nantong University, Nantong, China.
Lei WeiDepartment of Anesthesiology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
Nantong University · CNAffiliated Hospital of Nantong University · CNNanjing Medical University · CNQingdao Women and Children's Hospital · CNSuzhou Municipal Hospital · CNYancheng First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation-associated chronic pain is a global clinical problem, affecting millions of people worldwide. However, the underlying mechanisms that mediate inflammation-associated chronic pain remain unclear. A rat model of cutaneous inflammation induced by Complete Freund's Adjuvant (CFA) has been widely used as an inflammation-induced pain hypersensitivity model. We present the transcriptomics profile of CFA-induced inflammation in the rat dorsal root ganglion (DRG)

Indexed as

AnimalsChronic PainDisease Models, AnimalFreund's AdjuvantGanglia, SpinalHigh-Throughput Nucleotide SequencingHyperalgesiaInflammationMaleRatsRats, Sprague-DawleyTranscription Factor AP-1Freund's AdjuvantTranscription Factor AP-1AP-1chronic painDNA methylationmulti-omicstranscriptomic (RNA-Seq)

Identifiers

PMID34122430
PMCPMC8194263
OpenAlexW3172800968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.